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Genetics of menstrual migraine: the molecular evidence

Journal Article


Abstract


  • Migraine is considered to be a multifactorial disorder in which genetic, environmental, and, in the case of menstrual and menstrually related migraine, hormonal events influence the phenotype. Certainly, the role of female sex hormones in migraine has been well established, yet the mechanism behind this well-known relationship remains unclear. This review focuses on the potential role of hormonally related genes in migraine, summarizes results of candidate gene studies to date, and discusses challenges and issues involved in interpreting hormone-related gene results. In light of the molecular evidence presented, we discuss future approaches for analysis with the view to elucidate the complex genetic architecture that underlies the disorder.

Publication Date


  • 2010

Citation


  • Colson, N. J., Fernandez, F. & Griffiths, L. R. (2010). Genetics of menstrual migraine: the molecular evidence. Current Pain and Headache Reports, 14 (5), 389-395.

Scopus Eid


  • 2-s2.0-77957122126

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3504

Has Global Citation Frequency


Number Of Pages


  • 6

Start Page


  • 389

End Page


  • 395

Volume


  • 14

Issue


  • 5

Abstract


  • Migraine is considered to be a multifactorial disorder in which genetic, environmental, and, in the case of menstrual and menstrually related migraine, hormonal events influence the phenotype. Certainly, the role of female sex hormones in migraine has been well established, yet the mechanism behind this well-known relationship remains unclear. This review focuses on the potential role of hormonally related genes in migraine, summarizes results of candidate gene studies to date, and discusses challenges and issues involved in interpreting hormone-related gene results. In light of the molecular evidence presented, we discuss future approaches for analysis with the view to elucidate the complex genetic architecture that underlies the disorder.

Publication Date


  • 2010

Citation


  • Colson, N. J., Fernandez, F. & Griffiths, L. R. (2010). Genetics of menstrual migraine: the molecular evidence. Current Pain and Headache Reports, 14 (5), 389-395.

Scopus Eid


  • 2-s2.0-77957122126

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3504

Has Global Citation Frequency


Number Of Pages


  • 6

Start Page


  • 389

End Page


  • 395

Volume


  • 14

Issue


  • 5