Skip to main content

EEG coherence in children with attention-deficit/hyperactivity disorder: Differences between good and poor responders to methylphenidate

Journal Article


Abstract


  • This retrospective study investigated differences in regional derivations of EEG coherence between good and

    poor responders to methylphenidate (MPH) in children (aged 8–12 years) with the combined type of

    attention-deficit/hyperactivity disorder (AD/HD). Participants included groups of good and poor male MPH

    responders and an aged-matched group of male controls. An eyes-closed, resting electroencephalogram

    (EEG) was recorded from 21 electrode sites. Coherence was calculated from eight intrahemispheric and eight

    interhemispheric electrode pairs, for the delta, theta, alpha and beta frequency bands. Compared with

    controls, the AD/HD participants had enhanced laterality over short-medium inter-electrode distances, and

    elevated frontal interhemispheric coherences, in the theta band. Good MPH responders had higher

    intrahemispheric coherences than poor MPH responders over short-medium and long inter-electrode

    distances in the beta band. Enhanced laterality at short-medium inter-electrode distances suggests that the

    AD/HD children may have a developmental lag in short-axonal connections in the left hemisphere. Elevated

    frontal interhemispheric theta coherence consistently indicates some frontal dysfunction in AD/HD. The beta

    coherence differences found between good and poor MPH responders could indicate that good MPH

    responders have some type of structural dysfunction associated with cortical connections involved in

    attention/arousal.

Authors


  •   Mackie, Franca E. (external author)
  •   Clarke, Adam R.
  •   Barry, Robert J.
  •   McCarthy, Rory (external author)
  •   Selikowitz, Mark (external author)

Publication Date


  • 2010

Citation


  • Dupuy, F. E., Clarke, A. R., Barry, R. J., McCarthy, R. & Selikowitz, M. (2010). EEG coherence in children with attention-deficit/hyperactivity disorder: Differences between good and poor responders to methylphenidate. Psychiatry Research, 180 (2-3), 114-119.

Scopus Eid


  • 2-s2.0-78650710679

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3498

Number Of Pages


  • 5

Start Page


  • 114

End Page


  • 119

Volume


  • 180

Issue


  • 2-3

Place Of Publication


  • http://www.elsevier.com/wps/find/journaldescription.cws_home/522773/description#description

Abstract


  • This retrospective study investigated differences in regional derivations of EEG coherence between good and

    poor responders to methylphenidate (MPH) in children (aged 8–12 years) with the combined type of

    attention-deficit/hyperactivity disorder (AD/HD). Participants included groups of good and poor male MPH

    responders and an aged-matched group of male controls. An eyes-closed, resting electroencephalogram

    (EEG) was recorded from 21 electrode sites. Coherence was calculated from eight intrahemispheric and eight

    interhemispheric electrode pairs, for the delta, theta, alpha and beta frequency bands. Compared with

    controls, the AD/HD participants had enhanced laterality over short-medium inter-electrode distances, and

    elevated frontal interhemispheric coherences, in the theta band. Good MPH responders had higher

    intrahemispheric coherences than poor MPH responders over short-medium and long inter-electrode

    distances in the beta band. Enhanced laterality at short-medium inter-electrode distances suggests that the

    AD/HD children may have a developmental lag in short-axonal connections in the left hemisphere. Elevated

    frontal interhemispheric theta coherence consistently indicates some frontal dysfunction in AD/HD. The beta

    coherence differences found between good and poor MPH responders could indicate that good MPH

    responders have some type of structural dysfunction associated with cortical connections involved in

    attention/arousal.

Authors


  •   Mackie, Franca E. (external author)
  •   Clarke, Adam R.
  •   Barry, Robert J.
  •   McCarthy, Rory (external author)
  •   Selikowitz, Mark (external author)

Publication Date


  • 2010

Citation


  • Dupuy, F. E., Clarke, A. R., Barry, R. J., McCarthy, R. & Selikowitz, M. (2010). EEG coherence in children with attention-deficit/hyperactivity disorder: Differences between good and poor responders to methylphenidate. Psychiatry Research, 180 (2-3), 114-119.

Scopus Eid


  • 2-s2.0-78650710679

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3498

Number Of Pages


  • 5

Start Page


  • 114

End Page


  • 119

Volume


  • 180

Issue


  • 2-3

Place Of Publication


  • http://www.elsevier.com/wps/find/journaldescription.cws_home/522773/description#description