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Activation of signal pathways and the resistance to anti-EGFR treatment in colorectal cancer

Journal Article


Abstract


  • Colorectal cancer is the third most common cancer with a 5-year survival rate of less than 10%. It is caused by alterations of multiple signal pathways which are affected by both genetic and environmental factors. In some cases, EGFR is important in the carcinogenesis of colorectal cancer suggesting anti-EGFR therapy may be a potential treatment option. However, in other cases it is not effective, which may be related to its down-stream targeted gene mutations. KRAS is highly emphasized in the literature but other mutations like Src, PIK3CA, and BRAF may also be important. Furthermore, obesity may decrease the effectiveness of anti-EGFR treatment as it increases the risk factors for colorectal cancer. Using next-generation sequencing technology, it may be possible to identify all gene mutations in an individual with colorectal cancer. Therefore, gene mutations affecting anti-EGFR therapy in colorectal cancer patients can be identified.

Authors


  •   Chen, Jiezhong
  •   Huang, Xu-Feng
  •   Katsifis, Andrew (external author)

Publication Date


  • 2010

Citation


  • Chen, J., Huang, X. & Katsifis, A. (2010). Activation of signal pathways and the resistance to anti-EGFR treatment in colorectal cancer. Journal of Cellular Biochemistry, 111 (5), 1082-1086.

Scopus Eid


  • 2-s2.0-78649854654

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/202

Has Global Citation Frequency


Number Of Pages


  • 4

Start Page


  • 1082

End Page


  • 1086

Volume


  • 111

Issue


  • 5

Abstract


  • Colorectal cancer is the third most common cancer with a 5-year survival rate of less than 10%. It is caused by alterations of multiple signal pathways which are affected by both genetic and environmental factors. In some cases, EGFR is important in the carcinogenesis of colorectal cancer suggesting anti-EGFR therapy may be a potential treatment option. However, in other cases it is not effective, which may be related to its down-stream targeted gene mutations. KRAS is highly emphasized in the literature but other mutations like Src, PIK3CA, and BRAF may also be important. Furthermore, obesity may decrease the effectiveness of anti-EGFR treatment as it increases the risk factors for colorectal cancer. Using next-generation sequencing technology, it may be possible to identify all gene mutations in an individual with colorectal cancer. Therefore, gene mutations affecting anti-EGFR therapy in colorectal cancer patients can be identified.

Authors


  •   Chen, Jiezhong
  •   Huang, Xu-Feng
  •   Katsifis, Andrew (external author)

Publication Date


  • 2010

Citation


  • Chen, J., Huang, X. & Katsifis, A. (2010). Activation of signal pathways and the resistance to anti-EGFR treatment in colorectal cancer. Journal of Cellular Biochemistry, 111 (5), 1082-1086.

Scopus Eid


  • 2-s2.0-78649854654

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/202

Has Global Citation Frequency


Number Of Pages


  • 4

Start Page


  • 1082

End Page


  • 1086

Volume


  • 111

Issue


  • 5