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Synthesis of polyhydroxylated pyrrolizidine and indolizidine compounds and their glycosidase inhibitory activities

Journal Article


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Abstract


  • The synthesis of the natural product 3-epi-casuarine and two tricyclic ether bridged analogues, plus 7-deoxy-3,6-diepi-casuarine, 7-epi-australine, 1-epi-castanospermine and 1,6-diepi-castanospermine is described. The glycosidase inhibitory activities of these compounds, along with that of uniflorine A and other polyhydroxylated pyrrolizidines and indolizidines that we have published before, are reported. © 2010 Elsevier Ltd. All rights reserved.

UOW Authors


  •   Ritthiwigrom, Thunwadee (external author)
  •   Nash, Robert J. (external author)
  •   Pyne, Stephen

Publication Date


  • 2010

Citation


  • Ritthiwigrom, T., Nash, R. J. & Pyne, S. G. (2010). Synthesis of polyhydroxylated pyrrolizidine and indolizidine compounds and their glycosidase inhibitory activities. Tetrahedron, 66 (48), 9340-9347.

Scopus Eid


  • 2-s2.0-78049459822

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=7918&context=scipapers

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/4576

Number Of Pages


  • 7

Start Page


  • 9340

End Page


  • 9347

Volume


  • 66

Issue


  • 48

Abstract


  • The synthesis of the natural product 3-epi-casuarine and two tricyclic ether bridged analogues, plus 7-deoxy-3,6-diepi-casuarine, 7-epi-australine, 1-epi-castanospermine and 1,6-diepi-castanospermine is described. The glycosidase inhibitory activities of these compounds, along with that of uniflorine A and other polyhydroxylated pyrrolizidines and indolizidines that we have published before, are reported. © 2010 Elsevier Ltd. All rights reserved.

UOW Authors


  •   Ritthiwigrom, Thunwadee (external author)
  •   Nash, Robert J. (external author)
  •   Pyne, Stephen

Publication Date


  • 2010

Citation


  • Ritthiwigrom, T., Nash, R. J. & Pyne, S. G. (2010). Synthesis of polyhydroxylated pyrrolizidine and indolizidine compounds and their glycosidase inhibitory activities. Tetrahedron, 66 (48), 9340-9347.

Scopus Eid


  • 2-s2.0-78049459822

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=7918&context=scipapers

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/4576

Number Of Pages


  • 7

Start Page


  • 9340

End Page


  • 9347

Volume


  • 66

Issue


  • 48