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Synthesis of berberine-efflux pump inhibitor hybrid antibacterials

Journal Article


Abstract


  • This article describes the compact synthesis of two isomeric dual-action hybrid antimicrobials where the 13-position of the antibacterial berberine has been linked via 3′-and 4′-methylene bridges to INF55 (5-nitro-2-phenylindole), an inhibitor of the bacterial NorA multidrug-resistance pump. Copyright © Taylor & Francis Group, LLC.

Publication Date


  • 2010

Citation


  • Bremner, J. B. & Kelso, M. J. (2010). Synthesis of berberine-efflux pump inhibitor hybrid antibacterials. Synthetic Communications: an international journal for rapid communication of synthetic organic chem, 40 (23), 3561-3568.

Scopus Eid


  • 2-s2.0-78149430691

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/5145

Number Of Pages


  • 7

Start Page


  • 3561

End Page


  • 3568

Volume


  • 40

Issue


  • 23

Abstract


  • This article describes the compact synthesis of two isomeric dual-action hybrid antimicrobials where the 13-position of the antibacterial berberine has been linked via 3′-and 4′-methylene bridges to INF55 (5-nitro-2-phenylindole), an inhibitor of the bacterial NorA multidrug-resistance pump. Copyright © Taylor & Francis Group, LLC.

Publication Date


  • 2010

Citation


  • Bremner, J. B. & Kelso, M. J. (2010). Synthesis of berberine-efflux pump inhibitor hybrid antibacterials. Synthetic Communications: an international journal for rapid communication of synthetic organic chem, 40 (23), 3561-3568.

Scopus Eid


  • 2-s2.0-78149430691

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/5145

Number Of Pages


  • 7

Start Page


  • 3561

End Page


  • 3568

Volume


  • 40

Issue


  • 23