Abstract
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An efficient synthesis of 29 new binaphthyl-based neutral, and mono- and di-cationic, peptoids is described. Some of these compounds had antibacterial activities with MIC values of 1.9-3.9 mu g/mL against Staphylococcus aureus. One peptoid had a MIC value of 6 mu g/mL against a methicillin-resistant strain of S. aureus ( MRSA) and a MIC value of 2 mu g/mL against vancomycin-resistant strains of enterococci (VRE). (C) 2010 Elsevier Ltd. All rights reserved.