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Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1

Journal Article


Abstract

  • An efficient synthesis of 29 new binaphthyl-based neutral, and mono- and di-cationic, peptoids is described. Some of these compounds had antibacterial activities with MIC values of 1.9-3.9 mu g/mL against Staphylococcus aureus. One peptoid had a MIC value of 6 mu g/mL against a methicillin-resistant strain of S. aureus ( MRSA) and a MIC value of 2 mu g/mL against vancomycin-resistant strains of enterococci (VRE). (C) 2010 Elsevier Ltd. All rights reserved.

Authors

  •   Bremner, John B.
  •   Keller, Paul A.
  •   Pyne, Stephen G.
  •   Boyle, Timothy (external author)
  •   Brkic, Zinka (external author)
  •   David, Dorothy (external author)
  •   Robertson, Mark (external author)
  •   Somphol, Kittiya (external author)
  •   Baylis, Dean (external author)
  •   Coates, Jonathon A. (external author)
  •   Deadman, John (external author)
  •   Jeevarajah, Dharshini (external author)
  •   Rhodes, David I. (external author)

Publication Date

  • 2010

Citation

  • Bremner, J. B., Keller, P. A., Pyne, S. G., Boyle, T. P., Brkic, Z., David, D. M., Robertson, M., Somphol, K., Baylis, D., Coates, J., Deadman, J., Jeevarajah, D. & Rhodes, D. I. (2010). Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1. Bioorganic and Medicinal Chemistry, 18 (7), 2611-2620.

Scopus Eid

  • 2-s2.0-77950059532

Ro Metadata Url

  • http://ro.uow.edu.au/scipapers/5112

Number Of Pages

  • 9

Start Page

  • 2611

End Page

  • 2620

Volume

  • 18

Issue

  • 7

Abstract

  • An efficient synthesis of 29 new binaphthyl-based neutral, and mono- and di-cationic, peptoids is described. Some of these compounds had antibacterial activities with MIC values of 1.9-3.9 mu g/mL against Staphylococcus aureus. One peptoid had a MIC value of 6 mu g/mL against a methicillin-resistant strain of S. aureus ( MRSA) and a MIC value of 2 mu g/mL against vancomycin-resistant strains of enterococci (VRE). (C) 2010 Elsevier Ltd. All rights reserved.

Authors

  •   Bremner, John B.
  •   Keller, Paul A.
  •   Pyne, Stephen G.
  •   Boyle, Timothy (external author)
  •   Brkic, Zinka (external author)
  •   David, Dorothy (external author)
  •   Robertson, Mark (external author)
  •   Somphol, Kittiya (external author)
  •   Baylis, Dean (external author)
  •   Coates, Jonathon A. (external author)
  •   Deadman, John (external author)
  •   Jeevarajah, Dharshini (external author)
  •   Rhodes, David I. (external author)

Publication Date

  • 2010

Citation

  • Bremner, J. B., Keller, P. A., Pyne, S. G., Boyle, T. P., Brkic, Z., David, D. M., Robertson, M., Somphol, K., Baylis, D., Coates, J., Deadman, J., Jeevarajah, D. & Rhodes, D. I. (2010). Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1. Bioorganic and Medicinal Chemistry, 18 (7), 2611-2620.

Scopus Eid

  • 2-s2.0-77950059532

Ro Metadata Url

  • http://ro.uow.edu.au/scipapers/5112

Number Of Pages

  • 9

Start Page

  • 2611

End Page

  • 2620

Volume

  • 18

Issue

  • 7