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Polyterthiophene as an electrostimulated controlled drug release material of therapeutic levels of dexamethasone

Journal Article


Abstract


  • Polyterthiophene has been investigated as a substrate for the controlled release of dexamethasone, a synthetic glucocorticoid anti-inflammatory drug, which is widely used to help reduce inflammation in the central nervous system. Dexamethasone was incorporated into the polymer as an anionic dopant during electrochemical polymerisation from water-acetonitrile solutions. Optimal polymer synthesis conditions were established to yield reproducible dexamethasone release profiles into a simulated physiological receiving solution. A homogeneous morphology of the polyterthiophene substrate with minimal extraneous features was observed to be critical for achieving reproducibility of release. Release profiles were established using a range of electrochemical stimulation protocols over a 24h time period. The amount of dexamethasone released from the polyterthiophene under all electrostimulation protocols was at therapeutically relevant levels, with a maximum release of similar to 80 mu g/cm(2) achieved when the polymer film was in a reduced state. The oxidation state of the polyterthiophene was found to be critical for controlled release of the dexamethasone. Polyterthiophene doped with dexamethasone was observed to auto-reduce when placed into the receiving solution. As a consequence, no significant difference was observed between the unstimulated (auto-reduced) polymer and the electrochemically reduced polyterthiophene. By electrochemically holding the polyterthiophene in the oxidised state, the rate of release of dexamethasone was significantly impeded with similar to 40 mu g/cm(2) released over a 24h period. (C) 2010 Elsevier B.V. All rights reserved.

Publication Date


  • 2010

Citation


  • Stevenson, G., Moulton, S. E., Innis, P. C. & Wallace, G. G. (2010). Polyterthiophene as an electrostimulated controlled drug release material of therapeutic levels of dexamethasone. Synthetic Metals, 160 (9-10), 1107-1114.

Scopus Eid


  • 2-s2.0-77950938383

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/427

Has Global Citation Frequency


Number Of Pages


  • 7

Start Page


  • 1107

End Page


  • 1114

Volume


  • 160

Issue


  • 9-10

Abstract


  • Polyterthiophene has been investigated as a substrate for the controlled release of dexamethasone, a synthetic glucocorticoid anti-inflammatory drug, which is widely used to help reduce inflammation in the central nervous system. Dexamethasone was incorporated into the polymer as an anionic dopant during electrochemical polymerisation from water-acetonitrile solutions. Optimal polymer synthesis conditions were established to yield reproducible dexamethasone release profiles into a simulated physiological receiving solution. A homogeneous morphology of the polyterthiophene substrate with minimal extraneous features was observed to be critical for achieving reproducibility of release. Release profiles were established using a range of electrochemical stimulation protocols over a 24h time period. The amount of dexamethasone released from the polyterthiophene under all electrostimulation protocols was at therapeutically relevant levels, with a maximum release of similar to 80 mu g/cm(2) achieved when the polymer film was in a reduced state. The oxidation state of the polyterthiophene was found to be critical for controlled release of the dexamethasone. Polyterthiophene doped with dexamethasone was observed to auto-reduce when placed into the receiving solution. As a consequence, no significant difference was observed between the unstimulated (auto-reduced) polymer and the electrochemically reduced polyterthiophene. By electrochemically holding the polyterthiophene in the oxidised state, the rate of release of dexamethasone was significantly impeded with similar to 40 mu g/cm(2) released over a 24h period. (C) 2010 Elsevier B.V. All rights reserved.

Publication Date


  • 2010

Citation


  • Stevenson, G., Moulton, S. E., Innis, P. C. & Wallace, G. G. (2010). Polyterthiophene as an electrostimulated controlled drug release material of therapeutic levels of dexamethasone. Synthetic Metals, 160 (9-10), 1107-1114.

Scopus Eid


  • 2-s2.0-77950938383

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/427

Has Global Citation Frequency


Number Of Pages


  • 7

Start Page


  • 1107

End Page


  • 1114

Volume


  • 160

Issue


  • 9-10