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A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives

Journal Article


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Abstract


  • ESI mass spectrometry was used to assess the binding of 13-substituted, 5-nitro-2-phenylindolyl- and 2-naphthalenyl-based berberine derivatives to inter- and intramolecular G-quadruplex DNA molecules. In contrast with the parent berberine, the compounds showed selectivity for quadruplex over duplex DNA and stabilised the quadruplex structure. They represent a new class of quadruplex DNA-selective ligands. © 2010 The Royal Society of Chemistry.

Publication Date


  • 2010

Citation


  • Gornall, K., Samosorn, S., Tanwirat, B., Suksamrarn, A., Bremner, J. B., Kelso, M. J. & Beck, J. L. (2010). A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives. Chemical Communications, 46 (35), 6602-6604.

Scopus Eid


  • 2-s2.0-77956046998

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1457&context=scipapers

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/419

Number Of Pages


  • 2

Start Page


  • 6602

End Page


  • 6604

Volume


  • 46

Issue


  • 35

Abstract


  • ESI mass spectrometry was used to assess the binding of 13-substituted, 5-nitro-2-phenylindolyl- and 2-naphthalenyl-based berberine derivatives to inter- and intramolecular G-quadruplex DNA molecules. In contrast with the parent berberine, the compounds showed selectivity for quadruplex over duplex DNA and stabilised the quadruplex structure. They represent a new class of quadruplex DNA-selective ligands. © 2010 The Royal Society of Chemistry.

Publication Date


  • 2010

Citation


  • Gornall, K., Samosorn, S., Tanwirat, B., Suksamrarn, A., Bremner, J. B., Kelso, M. J. & Beck, J. L. (2010). A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives. Chemical Communications, 46 (35), 6602-6604.

Scopus Eid


  • 2-s2.0-77956046998

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1457&context=scipapers

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/419

Number Of Pages


  • 2

Start Page


  • 6602

End Page


  • 6604

Volume


  • 46

Issue


  • 35