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Synthesis of 2 '-aminoalkyl-1-benzylisoquinoline derivatives and medium sized ring analogues with mu opiod receptor binding activities

Journal Article


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Abstract


  • Novel 2'-aminoalkyl-1-benzylisoquinoline compounds and medium size ring analogues have been prepared using reductive alkylation methods. Four of these analogues were tested for biological activity across 48 different CNS receptors and were showed to have binding activities at the mu opiod receptor. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.

UOW Authors


  •   Mbere-Nguyen, Uta (external author)
  •   Ung, Alison T. (external author)
  •   Pyne, Stephen

Publication Date


  • 2010

Citation


  • Mbere-Nguyen, U., Ung, A. T. & Pyne, S. G. (2010). Synthesis of 2 '-aminoalkyl-1-benzylisoquinoline derivatives and medium sized ring analogues with mu opiod receptor binding activities. Tetrahedron, 66 (23), 4133-4143.

Scopus Eid


  • 2-s2.0-77953108171

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=7923&context=scipapers

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/4580

Number Of Pages


  • 10

Start Page


  • 4133

End Page


  • 4143

Volume


  • 66

Issue


  • 23

Abstract


  • Novel 2'-aminoalkyl-1-benzylisoquinoline compounds and medium size ring analogues have been prepared using reductive alkylation methods. Four of these analogues were tested for biological activity across 48 different CNS receptors and were showed to have binding activities at the mu opiod receptor. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.

UOW Authors


  •   Mbere-Nguyen, Uta (external author)
  •   Ung, Alison T. (external author)
  •   Pyne, Stephen

Publication Date


  • 2010

Citation


  • Mbere-Nguyen, U., Ung, A. T. & Pyne, S. G. (2010). Synthesis of 2 '-aminoalkyl-1-benzylisoquinoline derivatives and medium sized ring analogues with mu opiod receptor binding activities. Tetrahedron, 66 (23), 4133-4143.

Scopus Eid


  • 2-s2.0-77953108171

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=7923&context=scipapers

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/4580

Number Of Pages


  • 10

Start Page


  • 4133

End Page


  • 4143

Volume


  • 66

Issue


  • 23