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Effects of simvastatin and 6-hydroxydopamine on histaminergic H1 receptor binding density in rat brains

Journal Article


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Abstract


  • Statins have been widely used for the treatment of a variety of medical conditions including

    psychoneurological disorders beyond their original use in lowering cholesterol. Histamine receptors play

    an important role in the regulation of neural activity, however, it is unknown whether statins act on

    histamine receptors, particularly for their neural regulatory effects. This study examined the effects of

    simvastatin and 6-hydroxydopamine (6-OHDA) lesions on histamine H1 receptors using [3H] pyrilamine

    binding autoradiography. Compared to the saline group, simvastatin (1 mg/kg/day) significantly decreased H1 receptor bindings in the primary motor cortex (M1), ventromedial hypothalamic nucleus (VMH), caudate putamen (CPu), accumbens core (AcbC) and prefrontal cortex (PfC) (all pb0.05); however 10 mg/kg/day simvastatin increased H1 receptor density only in the medial amygdaloid nucleus (Mep) (pb0.05), but had no significant effect in other regions examined. The 6-OHDA lesion did not alter H1 receptor binding density in most brain areas, except a trend decrease in the hippocampus (p=0.07) and a trend increase in the cingulate cortex (p=0.06). These results suggested that simvastatin has different effects on the H1 receptors in different rat brain regions depending on the doses. Therefore, simvastatin can modulate histaminergic neurotransmission in the brain, and support the role of H1 receptors in psychoneurological disorders.

Authors


  •   Hu, Chang-Hua (external author)
  •   Deng, Chao
  •   Mackovski, Nikolce (external author)
  •   Long, Ling (external author)
  •   Zhu, Cansheng (external author)
  •   Yang, Yu (external author)
  •   Wang, Yuge (external author)
  •   Chen, Jiezhong
  •   Huang, Xu-Feng
  •   Wang, Dennis (external author)

Publication Date


  • 2010

Citation


  • Hu, C., Deng, C., Mackovski, N., Long, L., Zhu, C., Yang, Y., Wang, Y., Chen, J., Huang, X. & Wang, Q. (2010). Effects of simvastatin and 6-hydroxydopamine on histaminergic H1 receptor binding density in rat brains. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 34 (8), 1419-1425.

Scopus Eid


  • 2-s2.0-78649518546

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=4492&context=hbspapers

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3440

Has Global Citation Frequency


Number Of Pages


  • 6

Start Page


  • 1419

End Page


  • 1425

Volume


  • 34

Issue


  • 8

Place Of Publication


  • United States

Abstract


  • Statins have been widely used for the treatment of a variety of medical conditions including

    psychoneurological disorders beyond their original use in lowering cholesterol. Histamine receptors play

    an important role in the regulation of neural activity, however, it is unknown whether statins act on

    histamine receptors, particularly for their neural regulatory effects. This study examined the effects of

    simvastatin and 6-hydroxydopamine (6-OHDA) lesions on histamine H1 receptors using [3H] pyrilamine

    binding autoradiography. Compared to the saline group, simvastatin (1 mg/kg/day) significantly decreased H1 receptor bindings in the primary motor cortex (M1), ventromedial hypothalamic nucleus (VMH), caudate putamen (CPu), accumbens core (AcbC) and prefrontal cortex (PfC) (all pb0.05); however 10 mg/kg/day simvastatin increased H1 receptor density only in the medial amygdaloid nucleus (Mep) (pb0.05), but had no significant effect in other regions examined. The 6-OHDA lesion did not alter H1 receptor binding density in most brain areas, except a trend decrease in the hippocampus (p=0.07) and a trend increase in the cingulate cortex (p=0.06). These results suggested that simvastatin has different effects on the H1 receptors in different rat brain regions depending on the doses. Therefore, simvastatin can modulate histaminergic neurotransmission in the brain, and support the role of H1 receptors in psychoneurological disorders.

Authors


  •   Hu, Chang-Hua (external author)
  •   Deng, Chao
  •   Mackovski, Nikolce (external author)
  •   Long, Ling (external author)
  •   Zhu, Cansheng (external author)
  •   Yang, Yu (external author)
  •   Wang, Yuge (external author)
  •   Chen, Jiezhong
  •   Huang, Xu-Feng
  •   Wang, Dennis (external author)

Publication Date


  • 2010

Citation


  • Hu, C., Deng, C., Mackovski, N., Long, L., Zhu, C., Yang, Y., Wang, Y., Chen, J., Huang, X. & Wang, Q. (2010). Effects of simvastatin and 6-hydroxydopamine on histaminergic H1 receptor binding density in rat brains. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 34 (8), 1419-1425.

Scopus Eid


  • 2-s2.0-78649518546

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=4492&context=hbspapers

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3440

Has Global Citation Frequency


Number Of Pages


  • 6

Start Page


  • 1419

End Page


  • 1425

Volume


  • 34

Issue


  • 8

Place Of Publication


  • United States