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Guidance of neurite outgrowth on aligned electrospun polypyrrole/poly(styrene-β-isobutylene-β-styrene) fiber platforms

Journal Article


Abstract


  • The purpose of this work was to investigate the potential biomedical application of novel aligned electrospun polypyrrole (PPy)/poly(styrene-beta-isobutylene-beta-styrene) (SIBS) fibers. After successfully aligning the electroactive PPy/SIBS fibers based on our modified electrospinning method, we demonstrated that neurite outgrowth from PC12 cells could be highly orientated parallel to the aligned PPy/SIBS fibers. Physical interactions between the nerve cells and PPy/SIBS fibers through filopodia "sensing" were observed using atomic force microscopy. These observations indicate a role of contact guidance as a mechanism for the observed alignment. This work highlights the capacity for electroactive PPy/SIBS fibers to support and guide nerve cell differentiation through topographic cues, which is a highly desirable characteristic in medical implants for neurological applications. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res 94A: 1004-1011, 2010

Publication Date


  • 2010

Citation


  • Liu, X., Chen, J., Gilmore, K. J., Higgins, M. J., Liu, Y. & Wallace, G. G. (2010). Guidance of neurite outgrowth on aligned electrospun polypyrrole/poly(styrene-β-isobutylene-β-styrene) fiber platforms. Journal of Biomedical Materials Research Part A, 94A (4), 1004-1011.

Scopus Eid


  • 2-s2.0-77956458277

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/416

Has Global Citation Frequency


Number Of Pages


  • 7

Start Page


  • 1004

End Page


  • 1011

Volume


  • 94A

Issue


  • 4

Abstract


  • The purpose of this work was to investigate the potential biomedical application of novel aligned electrospun polypyrrole (PPy)/poly(styrene-beta-isobutylene-beta-styrene) (SIBS) fibers. After successfully aligning the electroactive PPy/SIBS fibers based on our modified electrospinning method, we demonstrated that neurite outgrowth from PC12 cells could be highly orientated parallel to the aligned PPy/SIBS fibers. Physical interactions between the nerve cells and PPy/SIBS fibers through filopodia "sensing" were observed using atomic force microscopy. These observations indicate a role of contact guidance as a mechanism for the observed alignment. This work highlights the capacity for electroactive PPy/SIBS fibers to support and guide nerve cell differentiation through topographic cues, which is a highly desirable characteristic in medical implants for neurological applications. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res 94A: 1004-1011, 2010

Publication Date


  • 2010

Citation


  • Liu, X., Chen, J., Gilmore, K. J., Higgins, M. J., Liu, Y. & Wallace, G. G. (2010). Guidance of neurite outgrowth on aligned electrospun polypyrrole/poly(styrene-β-isobutylene-β-styrene) fiber platforms. Journal of Biomedical Materials Research Part A, 94A (4), 1004-1011.

Scopus Eid


  • 2-s2.0-77956458277

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/416

Has Global Citation Frequency


Number Of Pages


  • 7

Start Page


  • 1004

End Page


  • 1011

Volume


  • 94A

Issue


  • 4