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Serum homocysteine and folate concentrations are associated with prevalent age-related hearing loss

Journal Article


Abstract


  • Elevated total serum homocysteine (tHcy) concentrations associated with vitamin B-12 or folate deficiencies may adversely affect blood flow to the cochlea, leading to age-related hearing loss (presbycusis). However, only 2 small cross-sectional studies have assessed the link between folate, vitamin B-12, or tHcy and presbycusis. We aimed to determine both the cross-sectional and longitudinal association between serum concentrations of folate, vitamin B-12, or tHcy and risk of age-related hearing loss. The Blue Mountains Hearing Study is a population-based survey of age-related hearing loss (1997–1999 to 2002–2004). Presbycusis was measured in 2956 participants (aged 50 y) and was defined as the pure-tone average of frequencies 0.5, 1.0, 2.0, and 4.0 kHz >25 dB hearing level (HL). Serum concentrations of folate, vitamin B-12, and tHcy were determined from blood samples. Participants with elevated tHcy (>20 µmol/L) concentrations had a 64% increased likelihood of prevalent hearing loss (>25 dB HL) [multivariate-adjusted odds ratio (OR) 1.64; 95% CI, 1.06–2.53]. Low serum folate levels (<11 nmol/L) increased the odds of prevalent mild hearing loss (>25–40 dB HL), multivariate-adjusted [OR 1.37 (CI 1.04–1.81)]. Serum vitamin B-12, however, was not significantly associated with prevalent hearing loss. Serum folate, vitamin B-12, and tHcy concentrations were also not significantly associated with an increased risk of incident hearing loss. Serum concentrations of tHcy and folate were associated with age-related hearing loss cross-sectionally, but no temporal links were observed, which could be due to insufficient study power. Further, large prospective studies will be required in the future to assess these associations.

UOW Authors


  •   Mitchell, Paul (external author)
  •   Gopinath, Bamini (external author)
  •   Rochtchina, Elena (external author)
  •   McMahon, Catherine M. (external author)
  •   Flood, Vicki M.

Publication Date


  • 2010

Citation


  • Gopinath, B., Flood, V. M., Rochtchina, E., McMahon, C. M. & Mitchell, P. (2010). Serum homocysteine and folate concentrations are associated with prevalent age-related hearing loss. The Journal of Nutrition, 140 (8), 1469-1474.

Scopus Eid


  • 2-s2.0-77955283203

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3435

Has Global Citation Frequency


Number Of Pages


  • 5

Start Page


  • 1469

End Page


  • 1474

Volume


  • 140

Issue


  • 8

Abstract


  • Elevated total serum homocysteine (tHcy) concentrations associated with vitamin B-12 or folate deficiencies may adversely affect blood flow to the cochlea, leading to age-related hearing loss (presbycusis). However, only 2 small cross-sectional studies have assessed the link between folate, vitamin B-12, or tHcy and presbycusis. We aimed to determine both the cross-sectional and longitudinal association between serum concentrations of folate, vitamin B-12, or tHcy and risk of age-related hearing loss. The Blue Mountains Hearing Study is a population-based survey of age-related hearing loss (1997–1999 to 2002–2004). Presbycusis was measured in 2956 participants (aged 50 y) and was defined as the pure-tone average of frequencies 0.5, 1.0, 2.0, and 4.0 kHz >25 dB hearing level (HL). Serum concentrations of folate, vitamin B-12, and tHcy were determined from blood samples. Participants with elevated tHcy (>20 µmol/L) concentrations had a 64% increased likelihood of prevalent hearing loss (>25 dB HL) [multivariate-adjusted odds ratio (OR) 1.64; 95% CI, 1.06–2.53]. Low serum folate levels (<11 nmol/L) increased the odds of prevalent mild hearing loss (>25–40 dB HL), multivariate-adjusted [OR 1.37 (CI 1.04–1.81)]. Serum vitamin B-12, however, was not significantly associated with prevalent hearing loss. Serum folate, vitamin B-12, and tHcy concentrations were also not significantly associated with an increased risk of incident hearing loss. Serum concentrations of tHcy and folate were associated with age-related hearing loss cross-sectionally, but no temporal links were observed, which could be due to insufficient study power. Further, large prospective studies will be required in the future to assess these associations.

UOW Authors


  •   Mitchell, Paul (external author)
  •   Gopinath, Bamini (external author)
  •   Rochtchina, Elena (external author)
  •   McMahon, Catherine M. (external author)
  •   Flood, Vicki M.

Publication Date


  • 2010

Citation


  • Gopinath, B., Flood, V. M., Rochtchina, E., McMahon, C. M. & Mitchell, P. (2010). Serum homocysteine and folate concentrations are associated with prevalent age-related hearing loss. The Journal of Nutrition, 140 (8), 1469-1474.

Scopus Eid


  • 2-s2.0-77955283203

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3435

Has Global Citation Frequency


Number Of Pages


  • 5

Start Page


  • 1469

End Page


  • 1474

Volume


  • 140

Issue


  • 8