The recent paper by Chintoh and colleagues (2008) reporting olanzapine-induced dysfunction
in glucose metabolism, enhanced visceral fat and reduced locomotor activity in female rats was
highly interesting as it illustrated olanzapine’s ability to replicate aspects of metabolic
dysfunction in the rodent model in a similar manner to the human scenario. However, contrary
to previous reports in the rat and the clinic, the authors reported no change in body weight or
food intake following olanzapine treatment, questioning the validity of the rat model.................