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Sensitivity of the female rat to olanzapine-induced weight gain - far from the clinic?

Journal Article


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Abstract


  • Dear Editor,

    The recent paper by Chintoh and colleagues (2008) reporting olanzapine-induced dysfunction

    in glucose metabolism, enhanced visceral fat and reduced locomotor activity in female rats was

    highly interesting as it illustrated olanzapine’s ability to replicate aspects of metabolic

    dysfunction in the rodent model in a similar manner to the human scenario. However, contrary

    to previous reports in the rat and the clinic, the authors reported no change in body weight or

    food intake following olanzapine treatment, questioning the validity of the rat model.................

Publication Date


  • 2010

Citation


  • Weston-Green, K., Huang, X. & Deng, C. (2010). Sensitivity of the female rat to olanzapine-induced weight gain - far from the clinic?. Schizophrenia Research, 116 (2-3), 299-300.

Scopus Eid


  • 2-s2.0-74449084653

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2408&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/1390

Has Global Citation Frequency


Number Of Pages


  • 1

Start Page


  • 299

End Page


  • 300

Volume


  • 116

Issue


  • 2-3

Place Of Publication


  • Netherlands

Abstract


  • Dear Editor,

    The recent paper by Chintoh and colleagues (2008) reporting olanzapine-induced dysfunction

    in glucose metabolism, enhanced visceral fat and reduced locomotor activity in female rats was

    highly interesting as it illustrated olanzapine’s ability to replicate aspects of metabolic

    dysfunction in the rodent model in a similar manner to the human scenario. However, contrary

    to previous reports in the rat and the clinic, the authors reported no change in body weight or

    food intake following olanzapine treatment, questioning the validity of the rat model.................

Publication Date


  • 2010

Citation


  • Weston-Green, K., Huang, X. & Deng, C. (2010). Sensitivity of the female rat to olanzapine-induced weight gain - far from the clinic?. Schizophrenia Research, 116 (2-3), 299-300.

Scopus Eid


  • 2-s2.0-74449084653

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2408&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/1390

Has Global Citation Frequency


Number Of Pages


  • 1

Start Page


  • 299

End Page


  • 300

Volume


  • 116

Issue


  • 2-3

Place Of Publication


  • Netherlands