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Interaction of estrogen with central serotonergic mechanisms in human sensory processing: loudness dependence of the auditory evoked potential and mismatch negativity

Journal Article


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Abstract


  • Estrogen may be involved in schizophrenia by inhibiting serotonin-1A (5 HT1A) receptor function, which is implicated in the pathophysiology of this illness. We examined the effects of estrogen pre-treatment on modulation of loudness dependence of the auditory evoked potential (LDAEP) and mismatch negativity (MMN) by the 5 HT1A receptor partial agonist, buspirone. Using a double-blind, placebo-controlled, repeated-measures design, in 16 healthy female volunteers, we observed that treatment with buspirone resulted in a significant increase of LDAEP slope, likely by inhibiting 5-HT function. Estrogen increased LDAEP slope on its own, and blocked a further increase by buspirone. Similar results were observed for MMN, where buspirone caused a small, but significant increase of latency, although not amplitude, after placebo pre-treatment. This effect was not seen after estrogen pre-treatment, which enhanced MMN latency on its own. These results are in line with our previous findings on prepulse inhibition which also showed an inhibitory effect of estrogen on the action of buspirone. Taken together, these data suggest that estrogen inhibits 5 HT1A receptor-mediated disruptions of auditory processing.

Authors


  •   Guille, Valerie (external author)
  •   Gogos, Andrea (external author)
  •   Nathan, Pradeep J. (external author)
  •   Croft, Rodney J.
  •   van den Buuse, Martin (external author)

Publication Date


  • 2011

Citation


  • Guille, V., Gogos, A., Nathan, P. J., Croft, R. J. & van den Buuse, M. (2011). Interaction of estrogen with central serotonergic mechanisms in human sensory processing: loudness dependence of the auditory evoked potential and mismatch negativity. Journal of Psychopharmacology, 25 (12), 1614-1622.

Scopus Eid


  • 2-s2.0-84856378840

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2095&context=hbspapers

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/1046

Has Global Citation Frequency


Number Of Pages


  • 8

Start Page


  • 1614

End Page


  • 1622

Volume


  • 25

Issue


  • 12

Place Of Publication


  • United Kingdom

Abstract


  • Estrogen may be involved in schizophrenia by inhibiting serotonin-1A (5 HT1A) receptor function, which is implicated in the pathophysiology of this illness. We examined the effects of estrogen pre-treatment on modulation of loudness dependence of the auditory evoked potential (LDAEP) and mismatch negativity (MMN) by the 5 HT1A receptor partial agonist, buspirone. Using a double-blind, placebo-controlled, repeated-measures design, in 16 healthy female volunteers, we observed that treatment with buspirone resulted in a significant increase of LDAEP slope, likely by inhibiting 5-HT function. Estrogen increased LDAEP slope on its own, and blocked a further increase by buspirone. Similar results were observed for MMN, where buspirone caused a small, but significant increase of latency, although not amplitude, after placebo pre-treatment. This effect was not seen after estrogen pre-treatment, which enhanced MMN latency on its own. These results are in line with our previous findings on prepulse inhibition which also showed an inhibitory effect of estrogen on the action of buspirone. Taken together, these data suggest that estrogen inhibits 5 HT1A receptor-mediated disruptions of auditory processing.

Authors


  •   Guille, Valerie (external author)
  •   Gogos, Andrea (external author)
  •   Nathan, Pradeep J. (external author)
  •   Croft, Rodney J.
  •   van den Buuse, Martin (external author)

Publication Date


  • 2011

Citation


  • Guille, V., Gogos, A., Nathan, P. J., Croft, R. J. & van den Buuse, M. (2011). Interaction of estrogen with central serotonergic mechanisms in human sensory processing: loudness dependence of the auditory evoked potential and mismatch negativity. Journal of Psychopharmacology, 25 (12), 1614-1622.

Scopus Eid


  • 2-s2.0-84856378840

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2095&context=hbspapers

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/1046

Has Global Citation Frequency


Number Of Pages


  • 8

Start Page


  • 1614

End Page


  • 1622

Volume


  • 25

Issue


  • 12

Place Of Publication


  • United Kingdom