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Electrophysiological measures as potential biomarkers in Huntington's disease: review and future directions

Journal Article


Abstract


  • Neuroimaging is fundamental to identifying quantifiable and objective biomarkers in symptomatic and pre-diagnostic Huntington’s disease (HD). Despite an increase of research efforts, the challenge remains to find reliable biomarkers with high sensitivity and specificity that can be used to track the functional decline over time and test efficacy of therapeutic intervention. While many recent studies have focused on neuroimaging techniques based on brain hemodynamic activity, comparatively less have utilized electroencephalography (EEG) and event-related potentials (ERPs). This review summarises and re-evaluates the key electroencephalographical findings over the last two decades in HD, with the goal to identify promising candidate biomarkers that could be sensitive in tracking disease progression.

Authors


  •   Nguyen, Lan (external author)
  •   Bradshaw, John L. (external author)
  •   Stout, Julie (external author)
  •   Croft, Rodney J.
  •   Georgiou-Karistianis, Nellie (external author)

Publication Date


  • 2010

Citation


  • Nguyen, L., Bradshaw, J., Stout, J., Croft, R. J. & Georgiou-Karistianis, N. (2010). Electrophysiological measures as potential biomarkers in Huntington's disease: review and future directions. Brain Research Reviews, 64 (1), 177-194.

Scopus Eid


  • 2-s2.0-77953358024

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/1743

Has Global Citation Frequency


Number Of Pages


  • 17

Start Page


  • 177

End Page


  • 194

Volume


  • 64

Issue


  • 1

Abstract


  • Neuroimaging is fundamental to identifying quantifiable and objective biomarkers in symptomatic and pre-diagnostic Huntington’s disease (HD). Despite an increase of research efforts, the challenge remains to find reliable biomarkers with high sensitivity and specificity that can be used to track the functional decline over time and test efficacy of therapeutic intervention. While many recent studies have focused on neuroimaging techniques based on brain hemodynamic activity, comparatively less have utilized electroencephalography (EEG) and event-related potentials (ERPs). This review summarises and re-evaluates the key electroencephalographical findings over the last two decades in HD, with the goal to identify promising candidate biomarkers that could be sensitive in tracking disease progression.

Authors


  •   Nguyen, Lan (external author)
  •   Bradshaw, John L. (external author)
  •   Stout, Julie (external author)
  •   Croft, Rodney J.
  •   Georgiou-Karistianis, Nellie (external author)

Publication Date


  • 2010

Citation


  • Nguyen, L., Bradshaw, J., Stout, J., Croft, R. J. & Georgiou-Karistianis, N. (2010). Electrophysiological measures as potential biomarkers in Huntington's disease: review and future directions. Brain Research Reviews, 64 (1), 177-194.

Scopus Eid


  • 2-s2.0-77953358024

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/1743

Has Global Citation Frequency


Number Of Pages


  • 17

Start Page


  • 177

End Page


  • 194

Volume


  • 64

Issue


  • 1