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Acute dopamine and/or serotonin depletion does not modulate mismatch negativity (MMN) in healthy human participants

Journal Article


Abstract


  • RATIONALE: Schizophrenia is commonly associated with impairments in pre-attentive change detection, as represented by reduced mismatch negativity (MMN). While the neurochemical basis of MMN has been linked to N-methyl-D: -aspartic acid (NMDA) receptor function, the roles of the dopaminergic and/or the serotonergic systems are not fully explored in humans. OBJECTIVES: The aim of the present study was to investigate the effects of acutely depleting dopamine (DA) and serotonin (5-hydroxytryptamine, 5-HT) alone or simultaneously by depleting their amino acid precursors on MMN in healthy participants. METHODS: Sixteen healthy male subjects participated in a double-blind, placebo-controlled, cross-over design in which each subject's duration MMN was assessed under four acute treatment conditions separated by a 5-day washout period: balanced amino acid control (no depletion), tyrosine/phenylalanine depletion (to reduce DA neurotransmission), tryptophan depletion (to reduce 5-HT neurotransmission) and tryptophan/tyrosine/phenylalanine depletion (to reduce DA and 5-HT neurotransmission simultaneously). RESULTS: Acute depletion of either DA and 5-HT alone or simultaneously had no effect on MMN. CONCLUSIONS: These findings suggest that modulation of the dopaminergic and serotonergic systems acutely does not lead to changes in MMN.

Authors


  •   Leung, Sumie (external author)
  •   Croft, Rodney J.
  •   Guille, Valerie (external author)
  •   Scholes, Kirsty E. (external author)
  •   O'Neill, Barry V. (external author)
  •   Phan, KL (external author)
  •   Nathan, Pradeep J. (external author)

Publication Date


  • 2010

Citation


  • Leung, S., Croft, R. J., Guille, V., Scholes, K., O'Neill, B. V., Phan, K. Luan. & Nathan, P. J. (2010). Acute dopamine and/or serotonin depletion does not modulate mismatch negativity (MMN) in healthy human participants. Psychopharmacology, 208 (2), 233-244.

Scopus Eid


  • 2-s2.0-77449146990

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3399

Has Global Citation Frequency


Number Of Pages


  • 11

Start Page


  • 233

End Page


  • 244

Volume


  • 208

Issue


  • 2

Abstract


  • RATIONALE: Schizophrenia is commonly associated with impairments in pre-attentive change detection, as represented by reduced mismatch negativity (MMN). While the neurochemical basis of MMN has been linked to N-methyl-D: -aspartic acid (NMDA) receptor function, the roles of the dopaminergic and/or the serotonergic systems are not fully explored in humans. OBJECTIVES: The aim of the present study was to investigate the effects of acutely depleting dopamine (DA) and serotonin (5-hydroxytryptamine, 5-HT) alone or simultaneously by depleting their amino acid precursors on MMN in healthy participants. METHODS: Sixteen healthy male subjects participated in a double-blind, placebo-controlled, cross-over design in which each subject's duration MMN was assessed under four acute treatment conditions separated by a 5-day washout period: balanced amino acid control (no depletion), tyrosine/phenylalanine depletion (to reduce DA neurotransmission), tryptophan depletion (to reduce 5-HT neurotransmission) and tryptophan/tyrosine/phenylalanine depletion (to reduce DA and 5-HT neurotransmission simultaneously). RESULTS: Acute depletion of either DA and 5-HT alone or simultaneously had no effect on MMN. CONCLUSIONS: These findings suggest that modulation of the dopaminergic and serotonergic systems acutely does not lead to changes in MMN.

Authors


  •   Leung, Sumie (external author)
  •   Croft, Rodney J.
  •   Guille, Valerie (external author)
  •   Scholes, Kirsty E. (external author)
  •   O'Neill, Barry V. (external author)
  •   Phan, KL (external author)
  •   Nathan, Pradeep J. (external author)

Publication Date


  • 2010

Citation


  • Leung, S., Croft, R. J., Guille, V., Scholes, K., O'Neill, B. V., Phan, K. Luan. & Nathan, P. J. (2010). Acute dopamine and/or serotonin depletion does not modulate mismatch negativity (MMN) in healthy human participants. Psychopharmacology, 208 (2), 233-244.

Scopus Eid


  • 2-s2.0-77449146990

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3399

Has Global Citation Frequency


Number Of Pages


  • 11

Start Page


  • 233

End Page


  • 244

Volume


  • 208

Issue


  • 2