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Cytotoxic and Antiplasmodial Compounds from the Roots of Strophioblachia fimbricalyx

Journal Article


Abstract


  • The known phenanthrenone trigonostemone (1), along with a new phenanthrenone, 9-O-demethyltrigonostemone (2), and two new phenanthropolones, 3,6,9-trimethoxyphenanthropolone (3) and 4,6,9-trimethoxyphenanthropolone (4), were isolated from the roots of Strophioblachia fimbricalyx. Compound 2 showed cytotoxicity against NCI-H187, KB, and MCF7 cancer cells with IC50 values of 0.8, 0.8, and 2.9 mu g/mL, respectively, while 3 and 4 showed reduced cytotoxicity. Compounds 2 and 3 displayed antiplasmodial activity in vitro (IC50 values of 2.7 and 3.2 mu g/mL, respectively) against Plasmodium falciparum (K1, resistant strain). In addition, the antioxidant activity of 1-4 toward DPPH radicals was determined, but only compound 2 showed any discernible activity.

UOW Authors


  •   Seephonkai, Prapairat (external author)
  •   Sangdee, Aphidech (external author)
  •   Bunchalee, Pasakorn (external author)
  •   Pyne, Stephen

Publication Date


  • 2009

Citation


  • Seephonkai, P., Sangdee, A., Bunchalee, P. & Pyne, S. G. (2009). Cytotoxic and Antiplasmodial Compounds from the Roots of Strophioblachia fimbricalyx. Journal of Natural Products, 72 (10), 1892-1894.

Scopus Eid


  • 2-s2.0-70350507094

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/4989

Number Of Pages


  • 2

Start Page


  • 1892

End Page


  • 1894

Volume


  • 72

Issue


  • 10

Abstract


  • The known phenanthrenone trigonostemone (1), along with a new phenanthrenone, 9-O-demethyltrigonostemone (2), and two new phenanthropolones, 3,6,9-trimethoxyphenanthropolone (3) and 4,6,9-trimethoxyphenanthropolone (4), were isolated from the roots of Strophioblachia fimbricalyx. Compound 2 showed cytotoxicity against NCI-H187, KB, and MCF7 cancer cells with IC50 values of 0.8, 0.8, and 2.9 mu g/mL, respectively, while 3 and 4 showed reduced cytotoxicity. Compounds 2 and 3 displayed antiplasmodial activity in vitro (IC50 values of 2.7 and 3.2 mu g/mL, respectively) against Plasmodium falciparum (K1, resistant strain). In addition, the antioxidant activity of 1-4 toward DPPH radicals was determined, but only compound 2 showed any discernible activity.

UOW Authors


  •   Seephonkai, Prapairat (external author)
  •   Sangdee, Aphidech (external author)
  •   Bunchalee, Pasakorn (external author)
  •   Pyne, Stephen

Publication Date


  • 2009

Citation


  • Seephonkai, P., Sangdee, A., Bunchalee, P. & Pyne, S. G. (2009). Cytotoxic and Antiplasmodial Compounds from the Roots of Strophioblachia fimbricalyx. Journal of Natural Products, 72 (10), 1892-1894.

Scopus Eid


  • 2-s2.0-70350507094

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/4989

Number Of Pages


  • 2

Start Page


  • 1892

End Page


  • 1894

Volume


  • 72

Issue


  • 10