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The synthesis of carbon-linked bisbenzylisoquinolines via ruthenium-mediated olefin-metathesis

Journal Article


Abstract


  • Novel laudanosine dinners in which two laudanosine units are linked at C-2' via a two and four-carbon linker have been prepared using ruthenium-mediated olefin-metathesis. In addition, a second four-carbon linker between the two isoquinoline N-atoms was also present leading to a novel macrocyclic ring system. Five of these compounds showed higher cytostatic activity on three cancer cell lines than thalicarpine. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.

UOW Authors


  •   Mbere-Nguyen, Uta (external author)
  •   Ung, Alison T. (external author)
  •   Pyne, Stephen

Publication Date


  • 2009

Citation


  • Mbere-Nguyen, U., Ung, A. T. & Pyne, S. G. (2009). The synthesis of carbon-linked bisbenzylisoquinolines via ruthenium-mediated olefin-metathesis. Tetrahedron, 65 (31), 5990-6000.

Scopus Eid


  • 2-s2.0-67649344103

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/4988

Number Of Pages


  • 10

Start Page


  • 5990

End Page


  • 6000

Volume


  • 65

Issue


  • 31

Abstract


  • Novel laudanosine dinners in which two laudanosine units are linked at C-2' via a two and four-carbon linker have been prepared using ruthenium-mediated olefin-metathesis. In addition, a second four-carbon linker between the two isoquinoline N-atoms was also present leading to a novel macrocyclic ring system. Five of these compounds showed higher cytostatic activity on three cancer cell lines than thalicarpine. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.

UOW Authors


  •   Mbere-Nguyen, Uta (external author)
  •   Ung, Alison T. (external author)
  •   Pyne, Stephen

Publication Date


  • 2009

Citation


  • Mbere-Nguyen, U., Ung, A. T. & Pyne, S. G. (2009). The synthesis of carbon-linked bisbenzylisoquinolines via ruthenium-mediated olefin-metathesis. Tetrahedron, 65 (31), 5990-6000.

Scopus Eid


  • 2-s2.0-67649344103

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/4988

Number Of Pages


  • 10

Start Page


  • 5990

End Page


  • 6000

Volume


  • 65

Issue


  • 31