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The synthesis of carbon linked bis-benzylisoquinolines using Mizoroki-Heck and Sonagashira coupling reactions

Journal Article


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Abstract


  • Novel laudanosine dimers in which two laudanosine units are linked at C-2' via a two or three-carbon linker (alkane, alkene or alkyne) have been prepared using palladium-catalysed cross-coupling reactions (Mizoroki-Heck and Sonagashira reactions). In one example, a second three-carbon linker between the two isoquinoline N-atoms was also present leading to a novel macrocyclic ring system. Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.

UOW Authors


  •   Mbere-Nguyen, Uta (external author)
  •   Ung, Alison T. (external author)
  •   Pyne, Stephen

Publication Date


  • 2009

Citation


  • Batenburg-Nguyen, U. T., Ung, A. T. & Pyne, S. G. (2009). The synthesis of carbon linked bis-benzylisoquinolines using Mizoroki-Heck and Sonagashira coupling reactions. Tetrahedron, 65 (1), 318-327.

Scopus Eid


  • 2-s2.0-56949097359

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=7924&context=scipapers

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/4581

Number Of Pages


  • 9

Start Page


  • 318

End Page


  • 327

Volume


  • 65

Issue


  • 1

Abstract


  • Novel laudanosine dimers in which two laudanosine units are linked at C-2' via a two or three-carbon linker (alkane, alkene or alkyne) have been prepared using palladium-catalysed cross-coupling reactions (Mizoroki-Heck and Sonagashira reactions). In one example, a second three-carbon linker between the two isoquinoline N-atoms was also present leading to a novel macrocyclic ring system. Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.

UOW Authors


  •   Mbere-Nguyen, Uta (external author)
  •   Ung, Alison T. (external author)
  •   Pyne, Stephen

Publication Date


  • 2009

Citation


  • Batenburg-Nguyen, U. T., Ung, A. T. & Pyne, S. G. (2009). The synthesis of carbon linked bis-benzylisoquinolines using Mizoroki-Heck and Sonagashira coupling reactions. Tetrahedron, 65 (1), 318-327.

Scopus Eid


  • 2-s2.0-56949097359

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=7924&context=scipapers

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/4581

Number Of Pages


  • 9

Start Page


  • 318

End Page


  • 327

Volume


  • 65

Issue


  • 1