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Increases in peptide Y-Y levels following oat ß-glucan ingestion are dose-dependent in overweight adults

Journal Article


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Abstract


  • Peptide Y-Y (PYY) is an anorexigenic hormone implicated in appetite control, andβ-glucan is a fiber known to affect appetite. We hypothesized that plasma PYY levels would increase in overweight human adults consuming increasing doses ofβ-glucan. The objective was to test whether the effect could be seen withβ-glucan delivered through extruded cereals containing a highβ-glucan oat bran with demonstrated high molecular weight and solubility. Fourteen subjects consumed a control meal and 3 cereals of varyingβ-glucan concentration (between 2.2 and 5.5 g), and blood samples were collected over 4 hours. Analysis of raw PYY data showed a trend toward significant increases over 4 hours. An increasing dose of β-glucan resulted in higher levels of plasma PYY, with significant differences between groups from 2 to 4 hours post test-meal. Data for the area under the curve analysis also approached significance, with post hoc analysis showing a difference (P = .039) between the control and the highest dose ofβ-glucan (5.5 g). The PYY levels at 4 hours were significantly different between the control and high-dose meal test (P = .036). There was a significant dose response, with a positive correlation between the grams ofβ-glucan and PYY area under the curve (r 2 = 0.994, P = .003). The optimal dose ofβ-glucan appears to lie between 4 and 6 g, with the effects on PYY mediated by viscosity and concentration. Meal-test studies examining a range of hormones should measure hormones over a minimum of 4 hours and record meal intake for even longer time frames.

Publication Date


  • 2009

Citation


  • Beck, E. J., Tapsell, L. C., Batterham, M. J., Tosh, S. M. & Huang, X. (2009). Increases in peptide Y-Y levels following oat ß-glucan ingestion are dose-dependent in overweight adults. Nutrition Research, 29 (10), 705-709.

Scopus Eid


  • 2-s2.0-77649224733

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1004&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/5

Has Global Citation Frequency


Number Of Pages


  • 4

Start Page


  • 705

End Page


  • 709

Volume


  • 29

Issue


  • 10

Place Of Publication


  • United States

Abstract


  • Peptide Y-Y (PYY) is an anorexigenic hormone implicated in appetite control, andβ-glucan is a fiber known to affect appetite. We hypothesized that plasma PYY levels would increase in overweight human adults consuming increasing doses ofβ-glucan. The objective was to test whether the effect could be seen withβ-glucan delivered through extruded cereals containing a highβ-glucan oat bran with demonstrated high molecular weight and solubility. Fourteen subjects consumed a control meal and 3 cereals of varyingβ-glucan concentration (between 2.2 and 5.5 g), and blood samples were collected over 4 hours. Analysis of raw PYY data showed a trend toward significant increases over 4 hours. An increasing dose of β-glucan resulted in higher levels of plasma PYY, with significant differences between groups from 2 to 4 hours post test-meal. Data for the area under the curve analysis also approached significance, with post hoc analysis showing a difference (P = .039) between the control and the highest dose ofβ-glucan (5.5 g). The PYY levels at 4 hours were significantly different between the control and high-dose meal test (P = .036). There was a significant dose response, with a positive correlation between the grams ofβ-glucan and PYY area under the curve (r 2 = 0.994, P = .003). The optimal dose ofβ-glucan appears to lie between 4 and 6 g, with the effects on PYY mediated by viscosity and concentration. Meal-test studies examining a range of hormones should measure hormones over a minimum of 4 hours and record meal intake for even longer time frames.

Publication Date


  • 2009

Citation


  • Beck, E. J., Tapsell, L. C., Batterham, M. J., Tosh, S. M. & Huang, X. (2009). Increases in peptide Y-Y levels following oat ß-glucan ingestion are dose-dependent in overweight adults. Nutrition Research, 29 (10), 705-709.

Scopus Eid


  • 2-s2.0-77649224733

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1004&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/5

Has Global Citation Frequency


Number Of Pages


  • 4

Start Page


  • 705

End Page


  • 709

Volume


  • 29

Issue


  • 10

Place Of Publication


  • United States