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Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials

Journal Article


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Abstract

  • An efficient synthesis of two new N-acetyl-4'-arylphenylalanines is described together with their incorporation into a number of cationic peptoid antibacterial agents, one of which had an MIC of 7.8 mu g/mL against Staphylococcus aureus.

UOW Authors

  •   Boyle, Timothy (external author)
  •   Bremner, John
  •   Coates, Jonathon A. (external author)
  •   Deadman, John (external author)
  •   Keller, Paul
  •   Pyne, Stephen
  •   Somphol, Kittiya (external author)

Publication Date

  • 2009

Citation

  • Boyle, T. P., Bremner, J. B., Coates, J. A., Deadman, J., Keller, P. A., Pyne, S. G. & Somphol, K. (2009). Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials. European Journal of Medicinal Chemistry, 44 (3), 1001-1009.

Scopus Eid

  • 2-s2.0-60549109879

Ro Full-text Url

  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=7919&context=scipapers

Ro Metadata Url

  • http://ro.uow.edu.au/scipapers/4575

Number Of Pages

  • 8

Start Page

  • 1001

End Page

  • 1009

Volume

  • 44

Issue

  • 3

Place Of Publication

  • http://www.elsevier.com/locate/ejmech

Abstract

  • An efficient synthesis of two new N-acetyl-4'-arylphenylalanines is described together with their incorporation into a number of cationic peptoid antibacterial agents, one of which had an MIC of 7.8 mu g/mL against Staphylococcus aureus.

UOW Authors

  •   Boyle, Timothy (external author)
  •   Bremner, John
  •   Coates, Jonathon A. (external author)
  •   Deadman, John (external author)
  •   Keller, Paul
  •   Pyne, Stephen
  •   Somphol, Kittiya (external author)

Publication Date

  • 2009

Citation

  • Boyle, T. P., Bremner, J. B., Coates, J. A., Deadman, J., Keller, P. A., Pyne, S. G. & Somphol, K. (2009). Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials. European Journal of Medicinal Chemistry, 44 (3), 1001-1009.

Scopus Eid

  • 2-s2.0-60549109879

Ro Full-text Url

  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=7919&context=scipapers

Ro Metadata Url

  • http://ro.uow.edu.au/scipapers/4575

Number Of Pages

  • 8

Start Page

  • 1001

End Page

  • 1009

Volume

  • 44

Issue

  • 3

Place Of Publication

  • http://www.elsevier.com/locate/ejmech