Skip to main content

Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials

Journal Article


Download full-text (Open Access)

Abstract


  • An efficient synthesis of two new N-acetyl-4'-arylphenylalanines is described together with their incorporation into a number of cationic peptoid antibacterial agents, one of which had an MIC of 7.8 mu g/mL against Staphylococcus aureus.

Publication Date


  • 2009

Citation


  • Boyle, T. P., Bremner, J. B., Coates, J. A., Deadman, J., Keller, P. A., Pyne, S. G. & Somphol, K. (2009). Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials. European Journal of Medicinal Chemistry, 44 (3), 1001-1009.

Scopus Eid


  • 2-s2.0-60549109879

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=7919&context=scipapers

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/4575

Number Of Pages


  • 8

Start Page


  • 1001

End Page


  • 1009

Volume


  • 44

Issue


  • 3

Place Of Publication


  • http://www.elsevier.com/locate/ejmech

Abstract


  • An efficient synthesis of two new N-acetyl-4'-arylphenylalanines is described together with their incorporation into a number of cationic peptoid antibacterial agents, one of which had an MIC of 7.8 mu g/mL against Staphylococcus aureus.

Publication Date


  • 2009

Citation


  • Boyle, T. P., Bremner, J. B., Coates, J. A., Deadman, J., Keller, P. A., Pyne, S. G. & Somphol, K. (2009). Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials. European Journal of Medicinal Chemistry, 44 (3), 1001-1009.

Scopus Eid


  • 2-s2.0-60549109879

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=7919&context=scipapers

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/4575

Number Of Pages


  • 8

Start Page


  • 1001

End Page


  • 1009

Volume


  • 44

Issue


  • 3

Place Of Publication


  • http://www.elsevier.com/locate/ejmech