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A study of intensity dependence of the auditory evoked potential (IDAEP) in medicated melancholic and non-melancholic depression

Journal Article


Abstract


  • BACKGROUND: Major Depressive Disorder is widely recognised to be a heterogeneous syndrome with numerous depressive phenotypes, one of which is melancholic depression. Patients with melancholic depression exhibit treatment responses and outcomes that differ from patients with non-melancholic depression. The current study aimed to assess whether differences existed between melancholic and non-melancholic subtypes of depression, as measured by the event related potential, intensity dependence of the auditory evoked potential (IDAEP). METHODS: IDAEP was assessed in 14 melancholic and 13 non-melancholic depressed subjects and 14 controls. RESULTS: The melancholic patients had a significantly shallower IDAEP slope than the non-melancholic patients not explained by depression severity or age. LIMITATIONS: Antidepressants were taken by all patients in this study and the effect of continual use of these drugs on the IDAEP slopes has yet to be confirmed. CONCLUSIONS: These results provide support for neurobiological differences between melancholic and non-melancholic depressive subtypes. Melancholic depression may be characterized by ongoing over function of the serotonin system in spite of medication treatment.

Authors


  •   Fitzgerald, Paul (external author)
  •   Below, Tessa (external author)
  •   Hoy, Kate (external author)
  •   Segrave, Rebecca A. (external author)
  •   Cooper, Nick (external author)
  •   Upton, Daniel (external author)
  •   Croft, Rodney J.

Publication Date


  • 2009

Citation


  • Fitzgerald, P., Below, T., Hoy, K., Segrave, R. A., Cooper, N., Upton, D. & Croft, R. J. (2009). A study of intensity dependence of the auditory evoked potential (IDAEP) in medicated melancholic and non-melancholic depression. Journal of Affective Disorders, 117 (3), 212-216.

Scopus Eid


  • 2-s2.0-69249223008

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3362

Has Global Citation Frequency


Number Of Pages


  • 4

Start Page


  • 212

End Page


  • 216

Volume


  • 117

Issue


  • 3

Abstract


  • BACKGROUND: Major Depressive Disorder is widely recognised to be a heterogeneous syndrome with numerous depressive phenotypes, one of which is melancholic depression. Patients with melancholic depression exhibit treatment responses and outcomes that differ from patients with non-melancholic depression. The current study aimed to assess whether differences existed between melancholic and non-melancholic subtypes of depression, as measured by the event related potential, intensity dependence of the auditory evoked potential (IDAEP). METHODS: IDAEP was assessed in 14 melancholic and 13 non-melancholic depressed subjects and 14 controls. RESULTS: The melancholic patients had a significantly shallower IDAEP slope than the non-melancholic patients not explained by depression severity or age. LIMITATIONS: Antidepressants were taken by all patients in this study and the effect of continual use of these drugs on the IDAEP slopes has yet to be confirmed. CONCLUSIONS: These results provide support for neurobiological differences between melancholic and non-melancholic depressive subtypes. Melancholic depression may be characterized by ongoing over function of the serotonin system in spite of medication treatment.

Authors


  •   Fitzgerald, Paul (external author)
  •   Below, Tessa (external author)
  •   Hoy, Kate (external author)
  •   Segrave, Rebecca A. (external author)
  •   Cooper, Nick (external author)
  •   Upton, Daniel (external author)
  •   Croft, Rodney J.

Publication Date


  • 2009

Citation


  • Fitzgerald, P., Below, T., Hoy, K., Segrave, R. A., Cooper, N., Upton, D. & Croft, R. J. (2009). A study of intensity dependence of the auditory evoked potential (IDAEP) in medicated melancholic and non-melancholic depression. Journal of Affective Disorders, 117 (3), 212-216.

Scopus Eid


  • 2-s2.0-69249223008

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/3362

Has Global Citation Frequency


Number Of Pages


  • 4

Start Page


  • 212

End Page


  • 216

Volume


  • 117

Issue


  • 3