This study recorded acute biochemical and subjective measures of satiety, followed by energy intake
from a subsequent meal, after varying doses of b-glucan in extruded breakfast cereals. Molecular
weight, solubility and viscosity of b-glucan products were determined. Seven male and seven female
subjects (BMI 25ÃÂÃÂ¢ÃÂÃÂÃÂÃÂ36 kg/m) consumed five breakfasts (different doses of b-glucan sourced from two
different technological processes) and dietary intake was measured after four hours. Blood was collected
to measure glucose, insulin, ghrelin and cholecystokinin, and visual analogue scales measured
subjective satiety. Molecular weight, solubility and viscosity indicated products were likely to increase luminal viscosity. b-Glucan was found to decrease insulin secretion over 2 h (RMANOVA, p = 0.011) in a dose responsive manner from 2.16 to 5.68 g per serving (p = 0.007). Cholecystokinin levels increased linearly over the same range of b-glucan concentrations (p = 0.002) in women. Subjective satiety was increased at a b-glucan dose of 2.2 g (p = 0.039). Subsequent meal intake decreased by greater than 400 kJ with higher b-glucan dose (A5 g). b-Glucan improves satiety and release of cholecystokinin is likely to be part of the mechanism. Products with different sources of b-glucan provide similar benefits but each product requires individual testing.