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Related pathological changes of serotonin 2A, muscarinic M1 and GABA A receptors in the superior temporal gyrus in schizophrenia

Conference Paper


Abstract


  • The superior temporal gyrus (STG) is strongly implicated in the pathophysiology of schizophrenia, particularly with regards to auditory hallucinations. Purpose: The objective of this study was to investigate the relationships of pathological changes in 5-HT2A, muscarinic M1 and GABAA receptors in the STG of schizophrenia. Methods: Using in situ quantitative autoradiography, the bindings of 5-HT2A, muscarinic M1 and GABAA receptors in the STG were examined. Results: Significant decreases in binding density of 5-HT2A and M1 receptors were observed in schizophrenia patients in comparison with control subjects (n=8; p<0.05). However there was an increased density of GABAA receptor in the STG of schizophrenia (p<0.05). A clear positive correlation between 5-HT2A and muscarinic M1 receptor bindings (r=0.44, p=0.087) and negative correlations between muscarinic M1 and GABAA receptor

    bindings (r=-0.49, p=0.057) have been revealed. Conclusions: These results suggest that the related pathological alterations of the 5-HT2A, muscarinic M1 and GABAA receptors contribute to pathophysiology of the STG in schizophrenia. There is a possible mechanism of auditory hallucinations through interactions between 5-HT2A, muscarinic and GABA transmissions in the STG in schizophrenia.

Publication Date


  • 2009

Citation


  • Deng, C. & Huang, X. (2009). Related pathological changes of serotonin 2A, muscarinic M1 and GABA A receptors in the superior temporal gyrus in schizophrenia. Australian Neuroscience Society Annual Meeting (p. 37). Canberra, Australia: Australian Neuroscience Society Inc.

Ro Metadata Url


  • http://www.sallyjayconferences.com.au/ans2009/docs/ANS%202009%20Oral%20Abstracts.pdf

Start Page


  • 37

Place Of Publication


  • Canberra, Australia

Abstract


  • The superior temporal gyrus (STG) is strongly implicated in the pathophysiology of schizophrenia, particularly with regards to auditory hallucinations. Purpose: The objective of this study was to investigate the relationships of pathological changes in 5-HT2A, muscarinic M1 and GABAA receptors in the STG of schizophrenia. Methods: Using in situ quantitative autoradiography, the bindings of 5-HT2A, muscarinic M1 and GABAA receptors in the STG were examined. Results: Significant decreases in binding density of 5-HT2A and M1 receptors were observed in schizophrenia patients in comparison with control subjects (n=8; p<0.05). However there was an increased density of GABAA receptor in the STG of schizophrenia (p<0.05). A clear positive correlation between 5-HT2A and muscarinic M1 receptor bindings (r=0.44, p=0.087) and negative correlations between muscarinic M1 and GABAA receptor

    bindings (r=-0.49, p=0.057) have been revealed. Conclusions: These results suggest that the related pathological alterations of the 5-HT2A, muscarinic M1 and GABAA receptors contribute to pathophysiology of the STG in schizophrenia. There is a possible mechanism of auditory hallucinations through interactions between 5-HT2A, muscarinic and GABA transmissions in the STG in schizophrenia.

Publication Date


  • 2009

Citation


  • Deng, C. & Huang, X. (2009). Related pathological changes of serotonin 2A, muscarinic M1 and GABA A receptors in the superior temporal gyrus in schizophrenia. Australian Neuroscience Society Annual Meeting (p. 37). Canberra, Australia: Australian Neuroscience Society Inc.

Ro Metadata Url


  • http://www.sallyjayconferences.com.au/ans2009/docs/ANS%202009%20Oral%20Abstracts.pdf

Start Page


  • 37

Place Of Publication


  • Canberra, Australia