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Association study of a functional variant in intron 8 of the dopamine transporter gene and migraine susceptibility

Journal Article


Abstract


  • Migraine is a common, genetically influenced neurovascular disorder. The dopamine transporter gene is a candidate for migraine association studies. This study tested a functionally linked variable number tandem repeat (VNTR) in intron 8 of the dopamine transporter gene (DATInt8) in 550 migraine cases (401 with aura, 149 without aura) and 550 non-migraine controls. Chi-squared analysis of the DATInt8 revealed that the allele and genotype frequency distributions for migraine cases (including subtype analysis) and controls were not different (P > 0.1). These findings offer no evidence for an association of the DATInt8 with migraine with and without aura and therefore do not implicate the dopamine transporter gene as a modifier of migraine risk.

Authors


  •   McCallum, L. K.. (external author)
  •   Fernandez-Enright, Francesca E.
  •   Quinlan, S. (external author)
  •   Macartney, D. P.. (external author)
  •   Lea, Rod A. (external author)
  •   Griffiths, Lyn R. (external author)

Publication Date


  • 2007

Citation


  • McCallum, L. K.., Fernandez, F., Quinlan, S., Macartney, D. P.., Lea, R. A. & Griffiths, L. R. (2007). Association study of a functional variant in intron 8 of the dopamine transporter gene and migraine susceptibility. European Journal of Neurology, 14 (6), 706-707.

Scopus Eid


  • 2-s2.0-34249805444

Has Global Citation Frequency


Number Of Pages


  • 1

Start Page


  • 706

End Page


  • 707

Volume


  • 14

Issue


  • 6

Abstract


  • Migraine is a common, genetically influenced neurovascular disorder. The dopamine transporter gene is a candidate for migraine association studies. This study tested a functionally linked variable number tandem repeat (VNTR) in intron 8 of the dopamine transporter gene (DATInt8) in 550 migraine cases (401 with aura, 149 without aura) and 550 non-migraine controls. Chi-squared analysis of the DATInt8 revealed that the allele and genotype frequency distributions for migraine cases (including subtype analysis) and controls were not different (P > 0.1). These findings offer no evidence for an association of the DATInt8 with migraine with and without aura and therefore do not implicate the dopamine transporter gene as a modifier of migraine risk.

Authors


  •   McCallum, L. K.. (external author)
  •   Fernandez-Enright, Francesca E.
  •   Quinlan, S. (external author)
  •   Macartney, D. P.. (external author)
  •   Lea, Rod A. (external author)
  •   Griffiths, Lyn R. (external author)

Publication Date


  • 2007

Citation


  • McCallum, L. K.., Fernandez, F., Quinlan, S., Macartney, D. P.., Lea, R. A. & Griffiths, L. R. (2007). Association study of a functional variant in intron 8 of the dopamine transporter gene and migraine susceptibility. European Journal of Neurology, 14 (6), 706-707.

Scopus Eid


  • 2-s2.0-34249805444

Has Global Citation Frequency


Number Of Pages


  • 1

Start Page


  • 706

End Page


  • 707

Volume


  • 14

Issue


  • 6