Skip to main content
placeholder image

Acute high-dose glycine attenuates mismatch negativity (MMN) in healthy human controls

Journal Article


Abstract


  • RATIONALE: Schizophrenia is commonly associated with impairments in pre-attentive change detection as represented by reduced mismatch negativity (MMN). The neurochemical basis of MMN has been linked to N-methyl-D: -aspartate (NMDA) receptor function. Glycine augments NMDA receptor function via stimulation of the glycine modulatory site of the NMDA receptor and has been shown to effectively reduce negative symptoms in schizophrenia. However, no study has investigated the possible effects of high-dose glycine on MMN. Further, the physiological consequences of administering high-dose glycine in subjects with normal NMDA receptor function are unknown. OBJECTIVES: The aim of the present project was to investigate the acute effects of a single large dose of glycine on the human MMN in healthy subjects. MATERIALS AND METHODS: Sixteen healthy male subjects participated in a double blind, placebo-controlled, crossover design in which each subject was tested under two acute treatment conditions separated by a 1-week washout period; placebo and 0.8 g/kg glycine. The subjects were exposed to a duration-MMN paradigm with 50-ms standard tones (91%) and 100-ms deviant tones (9%). RESULTS: The results showed that glycine significantly attenuated duration MMN amplitude at frontal electrodes. There was no effect of glycine on MMN latencies or on amplitudes or latencies of N1, N2 and P3a. CONCLUSIONS: These findings suggest that an acute high dosage of glycine attenuates MMN in healthy controls, raising the possibility that optimal effects of glycine and other glycine agonists may depend on the integrity of the NMDA receptor system.

Authors


  •   Leung, Sumie (external author)
  •   Croft, Rodney J.
  •   O'Neill, Barry V. (external author)
  •   Nathan, Pradeep J. (external author)

Publication Date


  • 2008

Citation


  • Leung, S., Croft, R. J., O'Neill, B. & Nathan, P. J. (2008). Acute high-dose glycine attenuates mismatch negativity (MMN) in healthy human controls. Psychopharmacology, 196 (3), 451-460.

Scopus Eid


  • 2-s2.0-38849161583

Has Global Citation Frequency


Number Of Pages


  • 9

Start Page


  • 451

End Page


  • 460

Volume


  • 196

Issue


  • 3

Place Of Publication


  • Germany

Abstract


  • RATIONALE: Schizophrenia is commonly associated with impairments in pre-attentive change detection as represented by reduced mismatch negativity (MMN). The neurochemical basis of MMN has been linked to N-methyl-D: -aspartate (NMDA) receptor function. Glycine augments NMDA receptor function via stimulation of the glycine modulatory site of the NMDA receptor and has been shown to effectively reduce negative symptoms in schizophrenia. However, no study has investigated the possible effects of high-dose glycine on MMN. Further, the physiological consequences of administering high-dose glycine in subjects with normal NMDA receptor function are unknown. OBJECTIVES: The aim of the present project was to investigate the acute effects of a single large dose of glycine on the human MMN in healthy subjects. MATERIALS AND METHODS: Sixteen healthy male subjects participated in a double blind, placebo-controlled, crossover design in which each subject was tested under two acute treatment conditions separated by a 1-week washout period; placebo and 0.8 g/kg glycine. The subjects were exposed to a duration-MMN paradigm with 50-ms standard tones (91%) and 100-ms deviant tones (9%). RESULTS: The results showed that glycine significantly attenuated duration MMN amplitude at frontal electrodes. There was no effect of glycine on MMN latencies or on amplitudes or latencies of N1, N2 and P3a. CONCLUSIONS: These findings suggest that an acute high dosage of glycine attenuates MMN in healthy controls, raising the possibility that optimal effects of glycine and other glycine agonists may depend on the integrity of the NMDA receptor system.

Authors


  •   Leung, Sumie (external author)
  •   Croft, Rodney J.
  •   O'Neill, Barry V. (external author)
  •   Nathan, Pradeep J. (external author)

Publication Date


  • 2008

Citation


  • Leung, S., Croft, R. J., O'Neill, B. & Nathan, P. J. (2008). Acute high-dose glycine attenuates mismatch negativity (MMN) in healthy human controls. Psychopharmacology, 196 (3), 451-460.

Scopus Eid


  • 2-s2.0-38849161583

Has Global Citation Frequency


Number Of Pages


  • 9

Start Page


  • 451

End Page


  • 460

Volume


  • 196

Issue


  • 3

Place Of Publication


  • Germany