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Investigation between the S377G3 GATA-4 polymorphism and migraine

Journal Article


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Abstract


  • Migraine is a common and painful neurological disorder, with genetic and environmental components.

    Several conditions have been shown to be comorbid with migraine, notably a cardiac malformation affecting the interatrial septum and leading to patent foramen ovale (PFO). Mutations in the development regulatory gene GATA-4, located on human chromosome 8p23.1-p22, have been found to be responsible for some cases of congenital heart defects including PFO. To determine whether the GATA-4 gene is involved in migraine, the present study performed an association analysis of a common GATA-4 variant that results in a change of amino acid (S377G), in a large case/control population (275 unrelated Caucasian migraineurs versus 275 control individuals). The results showed that there was no significant association for this polymorphism between migraine and controls (chi-square = 0.84, P = 0.66). Thus it appears that the GATA-4 (S377G) mutation does not play a significant role in common migraine susceptibility.

Authors


  •   Chikhani, Sherin (external author)
  •   Fernandez-Enright, Francesca E.
  •   Poetter, Karl (external author)
  •   Toohey, Brendam (external author)
  •   Harvey, Ron (external author)
  •   Griffiths, Lyn R. (external author)

Publication Date


  • 2008

Citation


  • Chikhani, S., Fernandez, F., Poetter, K., Toohey, B., Harvey, R. & Griffiths, L. (2008). Investigation between the S377G3 GATA-4 polymorphism and migraine. The Open Neurology Journal, 2 35-38.

Scopus Eid


  • 2-s2.0-65649107987

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1975&context=sspapers

Ro Metadata Url


  • http://ro.uow.edu.au/sspapers/976

Number Of Pages


  • 3

Start Page


  • 35

End Page


  • 38

Volume


  • 2

Place Of Publication


  • http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2577932&blobtype=pdf

Abstract


  • Migraine is a common and painful neurological disorder, with genetic and environmental components.

    Several conditions have been shown to be comorbid with migraine, notably a cardiac malformation affecting the interatrial septum and leading to patent foramen ovale (PFO). Mutations in the development regulatory gene GATA-4, located on human chromosome 8p23.1-p22, have been found to be responsible for some cases of congenital heart defects including PFO. To determine whether the GATA-4 gene is involved in migraine, the present study performed an association analysis of a common GATA-4 variant that results in a change of amino acid (S377G), in a large case/control population (275 unrelated Caucasian migraineurs versus 275 control individuals). The results showed that there was no significant association for this polymorphism between migraine and controls (chi-square = 0.84, P = 0.66). Thus it appears that the GATA-4 (S377G) mutation does not play a significant role in common migraine susceptibility.

Authors


  •   Chikhani, Sherin (external author)
  •   Fernandez-Enright, Francesca E.
  •   Poetter, Karl (external author)
  •   Toohey, Brendam (external author)
  •   Harvey, Ron (external author)
  •   Griffiths, Lyn R. (external author)

Publication Date


  • 2008

Citation


  • Chikhani, S., Fernandez, F., Poetter, K., Toohey, B., Harvey, R. & Griffiths, L. (2008). Investigation between the S377G3 GATA-4 polymorphism and migraine. The Open Neurology Journal, 2 35-38.

Scopus Eid


  • 2-s2.0-65649107987

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1975&context=sspapers

Ro Metadata Url


  • http://ro.uow.edu.au/sspapers/976

Number Of Pages


  • 3

Start Page


  • 35

End Page


  • 38

Volume


  • 2

Place Of Publication


  • http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2577932&blobtype=pdf