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Relationship between HIV-RNA load in blood and semen in antiretroviral-naive and experienced men and effect of asymptomatic sexually transmissible infections

Journal Article


Abstract


  • We assessed the correlation between HIV-RNA viral load in blood (BPVL) and

    seminal plasma (SPVL) in a cross-sectional cohort of 119 asymptomatic,

    antiretroviral-naive and experienced HIV-1 subjects (BPVL < 50 copies/mL for

    minimum 12 months and stable on one drug regimen). The cohort was divided into 3

    groups: 2 according to the non nucleoside reverse transcriptase inhibitor (NNRTI)

    and protease inhibitor (PI) used, and 1 untreated group. At the initial visit,

    subjects were screened for gonorrhoea, chlamydia and syphilis. Blood was

    collected for CD4 count, BPVL, and general biochemistry and haematology. Semen

    was collected concurrently and SPVL determined by the NucliSens HIV-1 QT PCR

    (BioMerieux, Boxtel, The Netherlands). At a subsequent visit, a second semen

    sample was obtained and SPVL was repeated for 10 subjects on ART. All NNRTI

    subjects (n = 36, mean treatment 33 months +/- 14) and PI subjects (n = 45, mean

    treatment 31 months +/- 25) had BPVL < 50 copies/mL and SPVL < 250 copies/mL at

    baseline and with repeat sampling. 9/119 subjects (8%) had an asymptomatic STI; 4

    cases in the treated groups and 5 in the untreated group. Treated subjects were

    less likely to have an STI than untreated subjects. In conclusion, asymptomatic

    STIs had no effect on BPVL or SPVL in either treated group and SPVL remains

    undetectable over time. STIs minimally increase, or do not increase, SPVL in

    untreated patients. Our data supports the role of ART in lowering the risk of

    sexual transmission of HIV-1.

Authors


  •   Chan, Derek J. (external author)
  •   McNally, Leon (external author)
  •   Batterham, Marijka
  •   Smith, Don E. (external author)

Publication Date


  • 2008

Citation


  • Chan, D., McNally, L., Batterham, M. & Smith, D. E. (2008). Relationship between HIV-RNA load in blood and semen in antiretroviral-naive and experienced men and effect of asymptomatic sexually transmissible infections. Current HIV Research, 6 (2), 138-142.

Scopus Eid


  • 2-s2.0-41249086368

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/1704

Has Global Citation Frequency


Number Of Pages


  • 4

Start Page


  • 138

End Page


  • 142

Volume


  • 6

Issue


  • 2

Abstract


  • We assessed the correlation between HIV-RNA viral load in blood (BPVL) and

    seminal plasma (SPVL) in a cross-sectional cohort of 119 asymptomatic,

    antiretroviral-naive and experienced HIV-1 subjects (BPVL < 50 copies/mL for

    minimum 12 months and stable on one drug regimen). The cohort was divided into 3

    groups: 2 according to the non nucleoside reverse transcriptase inhibitor (NNRTI)

    and protease inhibitor (PI) used, and 1 untreated group. At the initial visit,

    subjects were screened for gonorrhoea, chlamydia and syphilis. Blood was

    collected for CD4 count, BPVL, and general biochemistry and haematology. Semen

    was collected concurrently and SPVL determined by the NucliSens HIV-1 QT PCR

    (BioMerieux, Boxtel, The Netherlands). At a subsequent visit, a second semen

    sample was obtained and SPVL was repeated for 10 subjects on ART. All NNRTI

    subjects (n = 36, mean treatment 33 months +/- 14) and PI subjects (n = 45, mean

    treatment 31 months +/- 25) had BPVL < 50 copies/mL and SPVL < 250 copies/mL at

    baseline and with repeat sampling. 9/119 subjects (8%) had an asymptomatic STI; 4

    cases in the treated groups and 5 in the untreated group. Treated subjects were

    less likely to have an STI than untreated subjects. In conclusion, asymptomatic

    STIs had no effect on BPVL or SPVL in either treated group and SPVL remains

    undetectable over time. STIs minimally increase, or do not increase, SPVL in

    untreated patients. Our data supports the role of ART in lowering the risk of

    sexual transmission of HIV-1.

Authors


  •   Chan, Derek J. (external author)
  •   McNally, Leon (external author)
  •   Batterham, Marijka
  •   Smith, Don E. (external author)

Publication Date


  • 2008

Citation


  • Chan, D., McNally, L., Batterham, M. & Smith, D. E. (2008). Relationship between HIV-RNA load in blood and semen in antiretroviral-naive and experienced men and effect of asymptomatic sexually transmissible infections. Current HIV Research, 6 (2), 138-142.

Scopus Eid


  • 2-s2.0-41249086368

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/1704

Has Global Citation Frequency


Number Of Pages


  • 4

Start Page


  • 138

End Page


  • 142

Volume


  • 6

Issue


  • 2