Skip to main content
placeholder image

Soy food consumption does not lower LDL cholesterol in either equol or nonequol producers

Journal Article


Abstract


  • Background: Health claims link soy protein (SP) consumption, through plasma cholesterol reduction, to a decreased risk of heart disease. Soy isoflavones (ISOs), particularly in individuals who produce equol, might also contribute to lipid lowering and thus reduce SP requirements.

    Objective: The objective was to examine the contributions of SP, ISOs, and equol to the hypocholesterolemic effects of soy foods.

    Design: Nonsoy consumers (33 men, 58 women) with a plasma total cholesterol (TChol) concentration 5.5 mmol/L participated in a double-blind, placebo-controlled, crossover intervention trial. The

    subjects consumed 3 diets for 6 wk each in random order, which consisted of foods providing a daily dose of 1) 24gSPand7080mg ISOs (diet S); 2) 12 g SP, 12 g dairy protein (DP), and 7080 mg

    ISOs (diet SD); and 3) 24 gDPwithout ISOs (diet D). Fasting plasma TChol, LDL cholesterol, HDL cholesterol, and triglycerides (TGs) were measured after each diet.

    Results: TChol was 3% lower with the S diet (0.17 0.06 mmol/L;P0.05) than with theDdiet, andTGswere4%lower with both the S (0.140.05 mmol/L; P0.05) and SD (0.120.05

    mmol/L; P 0.05) diets. There were no significant effects on LDL cholesterol, HDL cholesterol, or the TChol:HDL cholesterol ratio. On the basis of urinary ISOs, 30 subjects were equol producers. Lipids were not affected significantly by equol production.

    Conclusions: Regular consumption of foods providing 24 g SP/d from ISOs had no significant effect on plasma LDL cholesterol in mildly hypercholesterolemic subjects, regardless of equolproducing status. Am J Clin Nutr 2008;88:298 304.

Authors


  •   Thorp, A (external author)
  •   Howe, Peter R.C. (external author)
  •   Mori, Trevor A (external author)
  •   Coates, A (external author)
  •   Buckley, J (external author)
  •   Hodgson, Jo (external author)
  •   Mansour, Jackie (external author)
  •   Meyer, Barbara J.

Publication Date


  • 2008

Citation


  • Thorp, A. A., Howe, P., Mori, T., Coates, A. M., Buckley, J. D., Hodgson, J., Mansour, J. & Meyer, B. J. (2008). Soy food consumption does not lower LDL cholesterol in either equol or nonequol producers. American Journal of Clinical Nutrition, 88 (2), 298-304.

Scopus Eid


  • 2-s2.0-84950170927

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/1670

Has Global Citation Frequency


Number Of Pages


  • 6

Start Page


  • 298

End Page


  • 304

Volume


  • 88

Issue


  • 2

Abstract


  • Background: Health claims link soy protein (SP) consumption, through plasma cholesterol reduction, to a decreased risk of heart disease. Soy isoflavones (ISOs), particularly in individuals who produce equol, might also contribute to lipid lowering and thus reduce SP requirements.

    Objective: The objective was to examine the contributions of SP, ISOs, and equol to the hypocholesterolemic effects of soy foods.

    Design: Nonsoy consumers (33 men, 58 women) with a plasma total cholesterol (TChol) concentration 5.5 mmol/L participated in a double-blind, placebo-controlled, crossover intervention trial. The

    subjects consumed 3 diets for 6 wk each in random order, which consisted of foods providing a daily dose of 1) 24gSPand7080mg ISOs (diet S); 2) 12 g SP, 12 g dairy protein (DP), and 7080 mg

    ISOs (diet SD); and 3) 24 gDPwithout ISOs (diet D). Fasting plasma TChol, LDL cholesterol, HDL cholesterol, and triglycerides (TGs) were measured after each diet.

    Results: TChol was 3% lower with the S diet (0.17 0.06 mmol/L;P0.05) than with theDdiet, andTGswere4%lower with both the S (0.140.05 mmol/L; P0.05) and SD (0.120.05

    mmol/L; P 0.05) diets. There were no significant effects on LDL cholesterol, HDL cholesterol, or the TChol:HDL cholesterol ratio. On the basis of urinary ISOs, 30 subjects were equol producers. Lipids were not affected significantly by equol production.

    Conclusions: Regular consumption of foods providing 24 g SP/d from ISOs had no significant effect on plasma LDL cholesterol in mildly hypercholesterolemic subjects, regardless of equolproducing status. Am J Clin Nutr 2008;88:298 304.

Authors


  •   Thorp, A (external author)
  •   Howe, Peter R.C. (external author)
  •   Mori, Trevor A (external author)
  •   Coates, A (external author)
  •   Buckley, J (external author)
  •   Hodgson, Jo (external author)
  •   Mansour, Jackie (external author)
  •   Meyer, Barbara J.

Publication Date


  • 2008

Citation


  • Thorp, A. A., Howe, P., Mori, T., Coates, A. M., Buckley, J. D., Hodgson, J., Mansour, J. & Meyer, B. J. (2008). Soy food consumption does not lower LDL cholesterol in either equol or nonequol producers. American Journal of Clinical Nutrition, 88 (2), 298-304.

Scopus Eid


  • 2-s2.0-84950170927

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/1670

Has Global Citation Frequency


Number Of Pages


  • 6

Start Page


  • 298

End Page


  • 304

Volume


  • 88

Issue


  • 2