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Homozygosity of the interleukin-10 receptor 1 G330R allele Is Associated With Schizophrenia

Journal Article


Abstract


  • Infections of unknown origin and an altered immune response have been hypothesized to play a role in the pathogenesis of schizophrenia. We have previously identified two single nucleotide polymorphisms (SNPs) of the IL-10 receptor 1 (IL-10R1) causing a substitution of glycine 330 to arginine (G330R) and of serine 138 to glycine (S138G). A possible association between these IL-10R1 variants and schizophrenia has been investigated in the present study. DNA of 101 unrelated Austrian patients with a DSM-III-R (Diagnostic and Statistical Manual of Mental Disorders) consensus diagnosis of schizophrenia (n = 70) or schizoaffective disorder (n = 31) and DNA of 121 German schizophrenic patients (DSM-III-R) was analyzed for the presence of S138G and G330R by allele-specific multiplex PCRs. Data from patients were compared with 250 unrelated, psychiatric healthy controls. No difference in allele frequency was detected between patients and controls (G330R: 34.0% vs. 30.0%, P = 0.208; S138G: 19.7% vs. 16.6%, P = 0.235; by Fisher's exact test). However, there was a significant difference in genotype distribution (wt/wt, wt/mut, mut/mut) for G330R between patients (46.8%, 38.3%, 14.9%) and controls (47.6%, 44.8%, 7.6%; Fisher's test P = 0.032). No such difference was seen for S138G. Our results suggest that homozygosity of the IL-10R1 G330R allele is associated with schizophrenia and may contribute to the expression of disease phenotype in susceptible individuals.

UOW Authors


  •   Schosser, Alexandra (external author)
  •   Aschauer, Harald N. (external author)
  •   Wildenauer, Dieter B. (external author)
  •   Schwab, Sibylle
  •   Albus, Margot (external author)
  •   Maier, Wolfgang (external author)
  •   Schloegelhofer, Monika (external author)
  •   Leisch, Friedrich (external author)
  •   Hornik, Kurt (external author)
  •   Murray, Sarah S. (external author)
  •   Gasche, Christoph (external author)

Publication Date


  • 2007

Citation


  • Schosser, A., Aschauer, H. N., Wildenauer, D. B., Schwab, S. G., Albus, M., Maier, W., Schloegelhofer, M., Leisch, F., Hornik, K., Murray, S. S. & Gasche, C. (2007). Homozygosity of the interleukin-10 receptor 1 G330R allele Is Associated With Schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 144B (3), 347-350.

Scopus Eid


  • 2-s2.0-34247367971

Ro Metadata Url


  • http://ro.uow.edu.au/commpapers/1414

Number Of Pages


  • 3

Start Page


  • 347

End Page


  • 350

Volume


  • 144B

Issue


  • 3

Abstract


  • Infections of unknown origin and an altered immune response have been hypothesized to play a role in the pathogenesis of schizophrenia. We have previously identified two single nucleotide polymorphisms (SNPs) of the IL-10 receptor 1 (IL-10R1) causing a substitution of glycine 330 to arginine (G330R) and of serine 138 to glycine (S138G). A possible association between these IL-10R1 variants and schizophrenia has been investigated in the present study. DNA of 101 unrelated Austrian patients with a DSM-III-R (Diagnostic and Statistical Manual of Mental Disorders) consensus diagnosis of schizophrenia (n = 70) or schizoaffective disorder (n = 31) and DNA of 121 German schizophrenic patients (DSM-III-R) was analyzed for the presence of S138G and G330R by allele-specific multiplex PCRs. Data from patients were compared with 250 unrelated, psychiatric healthy controls. No difference in allele frequency was detected between patients and controls (G330R: 34.0% vs. 30.0%, P = 0.208; S138G: 19.7% vs. 16.6%, P = 0.235; by Fisher's exact test). However, there was a significant difference in genotype distribution (wt/wt, wt/mut, mut/mut) for G330R between patients (46.8%, 38.3%, 14.9%) and controls (47.6%, 44.8%, 7.6%; Fisher's test P = 0.032). No such difference was seen for S138G. Our results suggest that homozygosity of the IL-10R1 G330R allele is associated with schizophrenia and may contribute to the expression of disease phenotype in susceptible individuals.

UOW Authors


  •   Schosser, Alexandra (external author)
  •   Aschauer, Harald N. (external author)
  •   Wildenauer, Dieter B. (external author)
  •   Schwab, Sibylle
  •   Albus, Margot (external author)
  •   Maier, Wolfgang (external author)
  •   Schloegelhofer, Monika (external author)
  •   Leisch, Friedrich (external author)
  •   Hornik, Kurt (external author)
  •   Murray, Sarah S. (external author)
  •   Gasche, Christoph (external author)

Publication Date


  • 2007

Citation


  • Schosser, A., Aschauer, H. N., Wildenauer, D. B., Schwab, S. G., Albus, M., Maier, W., Schloegelhofer, M., Leisch, F., Hornik, K., Murray, S. S. & Gasche, C. (2007). Homozygosity of the interleukin-10 receptor 1 G330R allele Is Associated With Schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 144B (3), 347-350.

Scopus Eid


  • 2-s2.0-34247367971

Ro Metadata Url


  • http://ro.uow.edu.au/commpapers/1414

Number Of Pages


  • 3

Start Page


  • 347

End Page


  • 350

Volume


  • 144B

Issue


  • 3