Skip to main content

Tissue distribution of lignans in rats in response to diet, dose-response and competition with isoflavones

Journal Article


Download full-text (Open Access)

Abstract


  • This paper investigates the occurrence and distribution of the lignan metabolites enterodiol (END)

    and enterolactone (ENL) and the isoflavone daidzein (DAID) in rat tissues by use of liquid

    chromatography-electrospray ionization mass spectrometry (LC-ESI/MSn) following a variety of

    dietary regimes. Furthermore, we examined the dose-response and distribution of END and ENL in

    liver, testes, prostate, and lung, and we investigated the effects of competition between lignans and

    isoflavones on metabolite distribution. In liver, testes, prostate, and lung tissue, dose-related increases

    in END concentration were observed. In the testes, coadministration of 60 mg/kg secoisolariciresinol

    diglycoside (SDG) with 60 mg/kg isoflavones produced alterations in the resulting metabolite profile,

    causing increased END concentration and decreased DAID concentration. Results indicate lignan

    accumulation in tissues occurs, and coadministration of lignans with isoflavones affects the metabolite

    profile, with effects dependent on tissue type

Authors


  •   Murray, Tim (external author)
  •   Kang, Jinguo (external author)
  •   Astheimer, Lee B. (external author)
  •   Price, William E.

Publication Date


  • 2007

Citation


  • Murray, T., Kang, J., Astheimer, L. & Price, W. E. (2007). Tissue distribution of lignans in rats in response to diet, dose-response and competition with isoflavones. Journal of Agricultural and Food Chemistry, 55 (12), 4907-4912.

Scopus Eid


  • 2-s2.0-34250757515

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2172&context=scipapers

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/1107

Number Of Pages


  • 5

Start Page


  • 4907

End Page


  • 4912

Volume


  • 55

Issue


  • 12

Abstract


  • This paper investigates the occurrence and distribution of the lignan metabolites enterodiol (END)

    and enterolactone (ENL) and the isoflavone daidzein (DAID) in rat tissues by use of liquid

    chromatography-electrospray ionization mass spectrometry (LC-ESI/MSn) following a variety of

    dietary regimes. Furthermore, we examined the dose-response and distribution of END and ENL in

    liver, testes, prostate, and lung, and we investigated the effects of competition between lignans and

    isoflavones on metabolite distribution. In liver, testes, prostate, and lung tissue, dose-related increases

    in END concentration were observed. In the testes, coadministration of 60 mg/kg secoisolariciresinol

    diglycoside (SDG) with 60 mg/kg isoflavones produced alterations in the resulting metabolite profile,

    causing increased END concentration and decreased DAID concentration. Results indicate lignan

    accumulation in tissues occurs, and coadministration of lignans with isoflavones affects the metabolite

    profile, with effects dependent on tissue type

Authors


  •   Murray, Tim (external author)
  •   Kang, Jinguo (external author)
  •   Astheimer, Lee B. (external author)
  •   Price, William E.

Publication Date


  • 2007

Citation


  • Murray, T., Kang, J., Astheimer, L. & Price, W. E. (2007). Tissue distribution of lignans in rats in response to diet, dose-response and competition with isoflavones. Journal of Agricultural and Food Chemistry, 55 (12), 4907-4912.

Scopus Eid


  • 2-s2.0-34250757515

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2172&context=scipapers

Ro Metadata Url


  • http://ro.uow.edu.au/scipapers/1107

Number Of Pages


  • 5

Start Page


  • 4907

End Page


  • 4912

Volume


  • 55

Issue


  • 12