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Caffeine effects on ERPs and performance in an auditory Go/NoGo task

Journal Article


Abstract


  • Objective: Previous research has shown that caffeine produces a general increase in arousal. The present study examined caffeine-induced

    arousal effects on performance and auditory ERPs. We sought components showing amplitude changes without topography changes, as

    would be expected of a pure arousal amplification of source activity.

    Methods: The effects of a single oral dose of caffeine (250 mg) were examined in a randomised double-blind placebo-controlled repeatedmeasures

    cross-over study. Subjects abstained from caffeine for 4 h before the testing sessions, which were conducted, in the afternoon,

    one week apart. A simple auditory Go/NoGo task was used, with a random mix of 75 tones at 1000 Hz and 75 at 1500 Hz. All tones were

    60 dB SPL, 50 ms duration (rise/fall time 5 ms), with SOA 1100 ms.

    Results: There was a reduction in RT, but no effects on omission or commission errors. The major ERP effects of caffeine were focal

    rather than global increases in P1, P2 and P3b amplitudes to Go stimuli, with no changes in latency. There were no effects on N1 or

    N2 to Go stimuli, and no effects on any components in response to NoGo stimuli.

    Conclusions: The results suggest that caffeine differentially improves aspects of the processing related to response production and task

    performance, contrary to the widespread amplification of ERP component amplitudes, and latency reductions, expected of an increase

    in general arousal.

    Significance: These results add auditory ERP data to the list of complex effects of caffeine on brain function and behaviour. They appear

    to rule out a simple arousal interpretation, and suggest directions for future research.

Publication Date


  • 2007

Citation


  • Barry, R. J., Johnstone, S. J., Clarke, A. R., Rushby, J. A., Brown, C. & McKenzie, D. (2007). Caffeine effects on ERPs and performance in an auditory Go/NoGo task. Clinical Neurophysiology, 118 (12), 2692-2699.

Scopus Eid


  • 2-s2.0-36549064360

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/1641

Number Of Pages


  • 7

Start Page


  • 2692

End Page


  • 2699

Volume


  • 118

Issue


  • 12

Place Of Publication


  • www.elsevier.com/locate/clinph

Abstract


  • Objective: Previous research has shown that caffeine produces a general increase in arousal. The present study examined caffeine-induced

    arousal effects on performance and auditory ERPs. We sought components showing amplitude changes without topography changes, as

    would be expected of a pure arousal amplification of source activity.

    Methods: The effects of a single oral dose of caffeine (250 mg) were examined in a randomised double-blind placebo-controlled repeatedmeasures

    cross-over study. Subjects abstained from caffeine for 4 h before the testing sessions, which were conducted, in the afternoon,

    one week apart. A simple auditory Go/NoGo task was used, with a random mix of 75 tones at 1000 Hz and 75 at 1500 Hz. All tones were

    60 dB SPL, 50 ms duration (rise/fall time 5 ms), with SOA 1100 ms.

    Results: There was a reduction in RT, but no effects on omission or commission errors. The major ERP effects of caffeine were focal

    rather than global increases in P1, P2 and P3b amplitudes to Go stimuli, with no changes in latency. There were no effects on N1 or

    N2 to Go stimuli, and no effects on any components in response to NoGo stimuli.

    Conclusions: The results suggest that caffeine differentially improves aspects of the processing related to response production and task

    performance, contrary to the widespread amplification of ERP component amplitudes, and latency reductions, expected of an increase

    in general arousal.

    Significance: These results add auditory ERP data to the list of complex effects of caffeine on brain function and behaviour. They appear

    to rule out a simple arousal interpretation, and suggest directions for future research.

Publication Date


  • 2007

Citation


  • Barry, R. J., Johnstone, S. J., Clarke, A. R., Rushby, J. A., Brown, C. & McKenzie, D. (2007). Caffeine effects on ERPs and performance in an auditory Go/NoGo task. Clinical Neurophysiology, 118 (12), 2692-2699.

Scopus Eid


  • 2-s2.0-36549064360

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/1641

Number Of Pages


  • 7

Start Page


  • 2692

End Page


  • 2699

Volume


  • 118

Issue


  • 12

Place Of Publication


  • www.elsevier.com/locate/clinph