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Perinatal administration of PCP alters adult behaviour in female Sprague-Dawley rats

Journal Article


Abstract


  • Perinatal phencyclidine (PCP) treatment leads to neuronal damage and causes long-term behavioural alterations in rodents. This study examined

    the effects of perinatal PCP treatment on behaviour of adult rats in holeboard, elevated plus maze, social interaction and forced swim tests.

    PCP-treated rats displayed hyperactivity in the holeboard and forced swim tests. These persistent behavioural changes are relevant to the study of

    psychiatric disorders such as schizophrenia.

Publication Date


  • 2008

Citation


  • Du Bois, T. M., Huang, X. & Deng, C. (2008). Perinatal administration of PCP alters adult behaviour in female Sprague-Dawley rats. Behavioural Brain Research, 188 (2), 416-419.

Scopus Eid


  • 2-s2.0-39149104333

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/2148

Has Global Citation Frequency


Number Of Pages


  • 3

Start Page


  • 416

End Page


  • 419

Volume


  • 188

Issue


  • 2

Place Of Publication


  • Netherlands

Abstract


  • Perinatal phencyclidine (PCP) treatment leads to neuronal damage and causes long-term behavioural alterations in rodents. This study examined

    the effects of perinatal PCP treatment on behaviour of adult rats in holeboard, elevated plus maze, social interaction and forced swim tests.

    PCP-treated rats displayed hyperactivity in the holeboard and forced swim tests. These persistent behavioural changes are relevant to the study of

    psychiatric disorders such as schizophrenia.

Publication Date


  • 2008

Citation


  • Du Bois, T. M., Huang, X. & Deng, C. (2008). Perinatal administration of PCP alters adult behaviour in female Sprague-Dawley rats. Behavioural Brain Research, 188 (2), 416-419.

Scopus Eid


  • 2-s2.0-39149104333

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/2148

Has Global Citation Frequency


Number Of Pages


  • 3

Start Page


  • 416

End Page


  • 419

Volume


  • 188

Issue


  • 2

Place Of Publication


  • Netherlands