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Fish oil supplementation in the treatment of major depression: A randomised double-blind placebo-controlled trial

Journal Article


Abstract


  • Dietary deficiencies in essential omega-3 polyunsaturated fatty acids derived from fish are associated with depression and some fish oils may

    have therapeutic benefits. We aimed to determine whether taking tuna fish oil confers any additional benefit to conventional outpatient treatment

    for major depression. A randomized double-blind placebo-controlled four-month trial comparing tuna fish oil versus placebo was conducted on 83

    outpatients with major depression. Despite large reductions in depression there were no significant differences at any assessment time point

    between patients receiving fish oil compared to placebo. Red blood cell incorporation of fatty acids indicated good compliance with oil

    supplementation, although this sample was not initially deficient in omega-3s. This particular dose and type of fish oil conferred no additional

    benefit to conventional treatment of depression in this sample. Future studies could target participants with pre-existing omega-3 deficiency and

    appraise alternate enriched types and higher doses of omega-3 supplementation.

Publication Date


  • 2007

Citation


  • Grenyer, B. F. S. ., Crowe, T., Meyer, B., Owen, A., Grigonis-Deane, E., Caputi, P. & Howe, P. (2007). Fish oil supplementation in the treatment of major depression: A randomised double-blind placebo-controlled trial. Neuro-Psychopharmacology & Biological Psychiatry, 31 1393-1396.

Scopus Eid


  • 2-s2.0-34548148482

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/1024

Has Global Citation Frequency


Number Of Pages


  • 3

Start Page


  • 1393

End Page


  • 1396

Volume


  • 31

Place Of Publication


  • United States

Abstract


  • Dietary deficiencies in essential omega-3 polyunsaturated fatty acids derived from fish are associated with depression and some fish oils may

    have therapeutic benefits. We aimed to determine whether taking tuna fish oil confers any additional benefit to conventional outpatient treatment

    for major depression. A randomized double-blind placebo-controlled four-month trial comparing tuna fish oil versus placebo was conducted on 83

    outpatients with major depression. Despite large reductions in depression there were no significant differences at any assessment time point

    between patients receiving fish oil compared to placebo. Red blood cell incorporation of fatty acids indicated good compliance with oil

    supplementation, although this sample was not initially deficient in omega-3s. This particular dose and type of fish oil conferred no additional

    benefit to conventional treatment of depression in this sample. Future studies could target participants with pre-existing omega-3 deficiency and

    appraise alternate enriched types and higher doses of omega-3 supplementation.

Publication Date


  • 2007

Citation


  • Grenyer, B. F. S. ., Crowe, T., Meyer, B., Owen, A., Grigonis-Deane, E., Caputi, P. & Howe, P. (2007). Fish oil supplementation in the treatment of major depression: A randomised double-blind placebo-controlled trial. Neuro-Psychopharmacology & Biological Psychiatry, 31 1393-1396.

Scopus Eid


  • 2-s2.0-34548148482

Ro Metadata Url


  • http://ro.uow.edu.au/hbspapers/1024

Has Global Citation Frequency


Number Of Pages


  • 3

Start Page


  • 1393

End Page


  • 1396

Volume


  • 31

Place Of Publication


  • United States