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Heads or tails? What is the important link between membrane phospholipids, body mass and metabolism?

Conference Paper


Abstract


  • The acyl composition of membrane phospholipids in kidney and brain of mammals of different body mass was examined. It was

    hypothesized that reduction in unsaturation index (number of double bonds per 100 acyl chains) of membrane phospholipids with

    increasing body mass in mammals would be made-up of similar changes in acyl composition across all phospholipid classes and

    that phospholipid class distribution would be regulated and similar in the same tissues of the different-sized mammals. The

    results of this study supported both hypotheses. Differences in membrane phospholipid acyl composition (i.e. decreased omega-

    3 fats, increased monounsaturated fats and decreased unsaturation index with increasing body size) were not restricted to any

    specific phospholipid molecule or to any specific phospholipid class but were observed in all phospholipid classes. With increase

    in body mass of mammals both monounsaturates and use of less unsaturated polyunsaturates increases at the expense of the

    long-chain highly unsaturated omega-3 and omega-6 polyunsaturates, producing decreases in membrane unsaturation. The

    distribution of membrane phospholipid classes was essentially the same in the different-sized mammals with phosphatidylcholine

    (PC) and phosphatidylethanolamine (PE) together constituting ~91% and ~88% of all phospholipids in kidney and brain,

    respectively. The lack of sphingomyelin in the mouse tissues and higher levels in larger mammals suggests an increased

    presence of membrane lipid rafts in larger mammals. The results of this study support the proposal that the physical properties

    of membranes are likely to be involved in changing metabolic rate.

Publication Date


  • 2007

Citation


  • Hughes, J. R., Blanksby, S. J., Else, P. & Mitchell, T. W. (2007). Heads or tails? What is the important link between membrane phospholipids, body mass and metabolism?. Australian and New Zealand Society for Mass Spectrometry 21st Conference (p. 65). Parkville Vic: ANZSMS Inc.

Ro Metadata Url


  • http://www.latrobe.edu.au/anzsms/Conferences.htm

Start Page


  • 65

Place Of Publication


  • http://www.latrobe.edu.au/anzsms/Conferences.htm

Abstract


  • The acyl composition of membrane phospholipids in kidney and brain of mammals of different body mass was examined. It was

    hypothesized that reduction in unsaturation index (number of double bonds per 100 acyl chains) of membrane phospholipids with

    increasing body mass in mammals would be made-up of similar changes in acyl composition across all phospholipid classes and

    that phospholipid class distribution would be regulated and similar in the same tissues of the different-sized mammals. The

    results of this study supported both hypotheses. Differences in membrane phospholipid acyl composition (i.e. decreased omega-

    3 fats, increased monounsaturated fats and decreased unsaturation index with increasing body size) were not restricted to any

    specific phospholipid molecule or to any specific phospholipid class but were observed in all phospholipid classes. With increase

    in body mass of mammals both monounsaturates and use of less unsaturated polyunsaturates increases at the expense of the

    long-chain highly unsaturated omega-3 and omega-6 polyunsaturates, producing decreases in membrane unsaturation. The

    distribution of membrane phospholipid classes was essentially the same in the different-sized mammals with phosphatidylcholine

    (PC) and phosphatidylethanolamine (PE) together constituting ~91% and ~88% of all phospholipids in kidney and brain,

    respectively. The lack of sphingomyelin in the mouse tissues and higher levels in larger mammals suggests an increased

    presence of membrane lipid rafts in larger mammals. The results of this study support the proposal that the physical properties

    of membranes are likely to be involved in changing metabolic rate.

Publication Date


  • 2007

Citation


  • Hughes, J. R., Blanksby, S. J., Else, P. & Mitchell, T. W. (2007). Heads or tails? What is the important link between membrane phospholipids, body mass and metabolism?. Australian and New Zealand Society for Mass Spectrometry 21st Conference (p. 65). Parkville Vic: ANZSMS Inc.

Ro Metadata Url


  • http://www.latrobe.edu.au/anzsms/Conferences.htm

Start Page


  • 65

Place Of Publication


  • http://www.latrobe.edu.au/anzsms/Conferences.htm