© 2020 Wiley-VCH GmbH Rechargeable alkali-metal–sulfur (M–S) batteries, because of their high energy density and low cost, have been recognized as one of the most promising next-generation energy storage technologies. Nevertheless, the dissolution of metal polysulfides in organic liquid electrolytes and safety issues related to the metal anodes are greatly hindering the development of the M–S batteries. Alkali-metal sulfides (M2Sx) are emerging as cathode materials, which can pair with various safe nonalkali-metal anodes, such as silicon and tin. As a result, the combined M2Sx cathode-based M–S batteries can achieve high capacity as well as safety, thereby providing a more feasible battery technology for practical applications. In this review, recent progress in developing M2Sx cathode-based M–S batteries is systematically summarized, including the activation methods for M2Sx cathodes, M2Sx cathode optimization, and the improvement of electrolytes and anode materials. Furthermore, perspectives and future research directions of M2Sx cathode-based M–S batteries are proposed.