Skip to main content
placeholder image

Characterization and antibacterial activity of phthalides from the roots of the mmedicinal herb levisticum officinale W.D.J. Koch

Journal Article


Abstract


  • © 2020, Iranian Journal of Pharmaceutical Research. All rights reserved. A new phthalide, namely 7-methoxy-3-propylidenephthalide (1), along with two known compounds (2, 3) were isolated from the roots of the edible herb Levisticum officinale W.D.J. Koch, commonly known as lovage and well known in traditional medicine for its spasmolytic and diuretic effects. The structure of the new compound was established by HRMS and 1D & 2D NMR (1H1H COSY, HMQC, and HMBC) spectroscopic analysis. All compounds are reported for the first time from L. officinale. Compounds 1-3 were tested against two Gram negative (Escherichia coli, Pseudomonas aeruginosa) and two Gram positive (Staphylococcus aureus and vancomycin-resistant Enterococcus [VRE] faecium) bacteria strains. Compound 3 was active against S. aureus, E. coli and vancomycin-resistant E. faecium with MIC values of 16, 64, and 128 μg/mL, respectively.

UOW Authors


  •   Miran, Mansour (external author)
  •   Monsef Esfahani, Hamidreza (external author)
  •   Jung, Jee (external author)
  •   Aliahmadi, Atousa (external author)
  •   Skropeta, Danielle
  •   Abbas-Mohammadi, Mahdi (external author)
  •   Nejad Ebrahimi, Samad (external author)
  •   Farimani, Mahdi (external author)

Publication Date


  • 2020

Citation


  • Miran, M., Monsef Esfahani, H., Jung, J., Aliahmadi, A., Skropeta, D., Abbas-Mohammadi, M., Nejad Ebrahimi, S. & Farimani, M. (2020). Characterization and antibacterial activity of phthalides from the roots of the mmedicinal herb levisticum officinale W.D.J. Koch. Iranian Journal of Pharmaceutical Research, 19 (2), 182-186.

Scopus Eid


  • 2-s2.0-85089512312

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/1521

Number Of Pages


  • 4

Start Page


  • 182

End Page


  • 186

Volume


  • 19

Issue


  • 2

Place Of Publication


  • Iran, Islamic Republic of

Abstract


  • © 2020, Iranian Journal of Pharmaceutical Research. All rights reserved. A new phthalide, namely 7-methoxy-3-propylidenephthalide (1), along with two known compounds (2, 3) were isolated from the roots of the edible herb Levisticum officinale W.D.J. Koch, commonly known as lovage and well known in traditional medicine for its spasmolytic and diuretic effects. The structure of the new compound was established by HRMS and 1D & 2D NMR (1H1H COSY, HMQC, and HMBC) spectroscopic analysis. All compounds are reported for the first time from L. officinale. Compounds 1-3 were tested against two Gram negative (Escherichia coli, Pseudomonas aeruginosa) and two Gram positive (Staphylococcus aureus and vancomycin-resistant Enterococcus [VRE] faecium) bacteria strains. Compound 3 was active against S. aureus, E. coli and vancomycin-resistant E. faecium with MIC values of 16, 64, and 128 μg/mL, respectively.

UOW Authors


  •   Miran, Mansour (external author)
  •   Monsef Esfahani, Hamidreza (external author)
  •   Jung, Jee (external author)
  •   Aliahmadi, Atousa (external author)
  •   Skropeta, Danielle
  •   Abbas-Mohammadi, Mahdi (external author)
  •   Nejad Ebrahimi, Samad (external author)
  •   Farimani, Mahdi (external author)

Publication Date


  • 2020

Citation


  • Miran, M., Monsef Esfahani, H., Jung, J., Aliahmadi, A., Skropeta, D., Abbas-Mohammadi, M., Nejad Ebrahimi, S. & Farimani, M. (2020). Characterization and antibacterial activity of phthalides from the roots of the mmedicinal herb levisticum officinale W.D.J. Koch. Iranian Journal of Pharmaceutical Research, 19 (2), 182-186.

Scopus Eid


  • 2-s2.0-85089512312

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/1521

Number Of Pages


  • 4

Start Page


  • 182

End Page


  • 186

Volume


  • 19

Issue


  • 2

Place Of Publication


  • Iran, Islamic Republic of