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Marine toxins targeting KV1 channels: Pharmacological tools and therapeutic scaffolds

Journal Article


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Abstract


  • Toxins from marine animals provide molecular tools for the study of many ion channels, including mammalian voltage-gated potassium channels of the Kv1 family. Selectivity profiling and molecular investigation of these toxins have contributed to the development of novel drug leads with therapeutic potential for the treatment of ion channel-related diseases or channelopathies. Here, we review specific peptide and small-molecule marine toxins modulating Kv1 channels and thus cover recent findings of bioactives found in the venoms of marine Gastropod (cone snails), Cnidarian (sea anemones), and small compounds from cyanobacteria. Furthermore, we discuss pivotal advancements at exploiting the interaction of κM-conotoxin RIIIJ and heteromeric Kv1.1/1.2 channels as prevalent neuronal Kv complex. RIIIJ's exquisite Kv1 subtype selectivity underpins a novel and facile functional classification of large-diameter dorsal root ganglion neurons. The vast potential of marine toxins warrants further collaborative efforts and high-throughput approaches aimed at the discovery and profiling of Kv1-targeted bioactives, which will greatly accelerate the development of a thorough molecular toolbox and much-needed therapeutics.

UOW Authors


  •   Finol Urdaneta, Rocio
  •   Belovanovic, Aleksandra (external author)
  •   Micic-Vicovac, Milica (external author)
  •   Kinsella, Gemma (external author)
  •   McArthur, Jeff R.
  •   Al-Sabi, Ahmed (external author)

Publication Date


  • 2020

Citation


  • Finol-Urdaneta, R. K., Belovanovic, A., Micic-Vicovac, M., Kinsella, G. K., McArthur, J. R. & Al-Sabi, A. (2020). Marine toxins targeting KV1 channels: Pharmacological tools and therapeutic scaffolds. Marine Drugs, 18 (3), 173-1-173-28.

Scopus Eid


  • 2-s2.0-85083041855

Ro Full-text Url


  • https://ro.uow.edu.au/cgi/viewcontent.cgi?article=2557&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/1529

Has Global Citation Frequency


Start Page


  • 173-1

End Page


  • 173-28

Volume


  • 18

Issue


  • 3

Place Of Publication


  • Switzerland

Abstract


  • Toxins from marine animals provide molecular tools for the study of many ion channels, including mammalian voltage-gated potassium channels of the Kv1 family. Selectivity profiling and molecular investigation of these toxins have contributed to the development of novel drug leads with therapeutic potential for the treatment of ion channel-related diseases or channelopathies. Here, we review specific peptide and small-molecule marine toxins modulating Kv1 channels and thus cover recent findings of bioactives found in the venoms of marine Gastropod (cone snails), Cnidarian (sea anemones), and small compounds from cyanobacteria. Furthermore, we discuss pivotal advancements at exploiting the interaction of κM-conotoxin RIIIJ and heteromeric Kv1.1/1.2 channels as prevalent neuronal Kv complex. RIIIJ's exquisite Kv1 subtype selectivity underpins a novel and facile functional classification of large-diameter dorsal root ganglion neurons. The vast potential of marine toxins warrants further collaborative efforts and high-throughput approaches aimed at the discovery and profiling of Kv1-targeted bioactives, which will greatly accelerate the development of a thorough molecular toolbox and much-needed therapeutics.

UOW Authors


  •   Finol Urdaneta, Rocio
  •   Belovanovic, Aleksandra (external author)
  •   Micic-Vicovac, Milica (external author)
  •   Kinsella, Gemma (external author)
  •   McArthur, Jeff R.
  •   Al-Sabi, Ahmed (external author)

Publication Date


  • 2020

Citation


  • Finol-Urdaneta, R. K., Belovanovic, A., Micic-Vicovac, M., Kinsella, G. K., McArthur, J. R. & Al-Sabi, A. (2020). Marine toxins targeting KV1 channels: Pharmacological tools and therapeutic scaffolds. Marine Drugs, 18 (3), 173-1-173-28.

Scopus Eid


  • 2-s2.0-85083041855

Ro Full-text Url


  • https://ro.uow.edu.au/cgi/viewcontent.cgi?article=2557&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/1529

Has Global Citation Frequency


Start Page


  • 173-1

End Page


  • 173-28

Volume


  • 18

Issue


  • 3

Place Of Publication


  • Switzerland