Introduction:The human papilloma virus (HPV) vaccine is effective in preventing HPV-related diseases, including cervical cancer, which killed 270,000 females in 2015. Approximately 118 million females worldwide have received the HPV vaccine since 2006. However, only 1 percent were from low-and-middle income countries, where 90% of deaths occur. As parents play a vital role in allowing their daughters to receive the vaccine, there is a need to understand parents’ attitudes to the HPV vaccine. Methods: A comprehensive literature review was undertaken. Seven electronic databases were searched for papers published between 2008 and 2018 and supplemented with hand searching. Papers were included if they were in English, full text, peer-reviewed, and had a focus on parents’ knowledge, attitudes, beliefs and uptake to the HPV vaccine. Forty six papers were included in the final review.Results:Three themes were identified as vital predictors for acceptance among parents: knowledge of the vaccine and HPV-related diseases; recommendations from health care providers; and the monetary cost associated with vaccination. A lack of knowledge about what causes cervical cancer and the efficacy of the vaccine exists, as does a belief that their daughters aretoo young to be vaccinated asthey are not yet sexually active. Conclusion/Recommendations:Increased efforts are required to clarify any misconceptions around sexual activity, the need for the vaccine and any side effects. Considering health care providers play a pivotal role in advising parents in low-and-middle income countries, routine recommendations from health care providers could benefit uptake of the HPV vaccine.