© 2020, Springer Nature Singapore Pte Ltd. Microencapsulated phase change materials (MEPCMs) have been recognized as potential energy storage materials which could be used for reducing energy consumption and improve indoor thermal comfort in buildings. However, current MEPCMs are limited by their singular phase change transitional temperatures and therefore unable to satisfy all year seasonal energy storage applications. This study was therefore focused on numerical assessment of the energy-saving potential of different types of MEPCM drywalls and a binary MEPCM drywall system by ESP-r. The simulation results showed that the laminated binary MEPCM drywall performed thermally better than the other types of walls over a period of the six months. In comparison with the building without MEPCM layer, the binary MEPCM drywall did reduce the peak indoor air temperature by 2.9–6.7 °C and was able to increase about 12% indoor thermal comfort time.