Introduction: Linking routinely collected health data provides an excellent opportunity to support the rapid translation of research findings into clinical practice and policy change. However, in regional Australia, there is often a lack of available infrastructure and research expertise to integrate and analyse multiple routinely collected data sets. This is essential to ensure data is safely and securely accessible to clinicians and researchers wanting to investigate locally relevant health priority areas. This strategy addresses this identified gap. Methods: A research partnership between the Illawarra Shoalhaven Local Health District and the University of Wollongong was established in 2016. The partnership founded the Centre for Health Research Illawarra Shoalhaven Population, a multidisciplinary research team, and the Illawarra Health Information Platform, a powerful stand-alone data repository and linkage information technology system, including up to 30 years of data from multiple providers.Results: This regional model has established governance and ethics approval processes, and enables multiple complex datasets to be securely managed, shared and analysed by the research collaborators. This model facilitates research capacity building both within the local health district and the university and disseminates research findings via peer reviewed publications, conference presentations and workshops (research translation and data analytics). Conclusion & Recommendation: This model demonstrates that research addressing local health priorities can be undertaken through the provision of a safe, secure and accessible data platform together with access to experienced multidisciplinary researchers. The model provides new opportunities for rapid research translationand should be used nationally as a regional demonstration framework.