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Polarisable force fields: what do they add in biomolecular simulations?

Journal Article


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Abstract


  • The quality of biomolecular simulations critically depends on the accuracy of the force field used to calculate the potential energy of the molecular configurations. Currently, most simulations employ non-polarisable force fields, which describe electrostatic interactions as the sum of Coulombic interactions between fixed atomic charges. Polarisation of these charge distributions is incorporated only in a mean-field manner. In the past decade, extensive efforts have been devoted to developing simple, efficient, and yet generally applicable polarisable force fields for biomolecular simulations. In this review, we summarise the latest developments in accounting for key biomolecular interactions with polarisable force fields and applications to address challenging biological questions. In the end, we provide an outlook for future development in polarisable force fields.

UOW Authors


  •   Inakollu, Venkatasaisandeep (external author)
  •   Geerke, Daan P. (external author)
  •   Rowley, Christopher N. (external author)
  •   Yu, Haibo

Publication Date


  • 2020

Citation


  • Inakollu, V. S., Geerke, D. P., Rowley, C. N. & Yu, H. (2020). Polarisable force fields: what do they add in biomolecular simulations?. Current Opinion in Structural Biology, 61 182-190.

Scopus Eid


  • 2-s2.0-85078971610

Ro Full-text Url


  • https://ro.uow.edu.au/cgi/viewcontent.cgi?article=2191&context=smhpapers1

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/1177

Has Global Citation Frequency


Number Of Pages


  • 8

Start Page


  • 182

End Page


  • 190

Volume


  • 61

Place Of Publication


  • United Kingdom

Abstract


  • The quality of biomolecular simulations critically depends on the accuracy of the force field used to calculate the potential energy of the molecular configurations. Currently, most simulations employ non-polarisable force fields, which describe electrostatic interactions as the sum of Coulombic interactions between fixed atomic charges. Polarisation of these charge distributions is incorporated only in a mean-field manner. In the past decade, extensive efforts have been devoted to developing simple, efficient, and yet generally applicable polarisable force fields for biomolecular simulations. In this review, we summarise the latest developments in accounting for key biomolecular interactions with polarisable force fields and applications to address challenging biological questions. In the end, we provide an outlook for future development in polarisable force fields.

UOW Authors


  •   Inakollu, Venkatasaisandeep (external author)
  •   Geerke, Daan P. (external author)
  •   Rowley, Christopher N. (external author)
  •   Yu, Haibo

Publication Date


  • 2020

Citation


  • Inakollu, V. S., Geerke, D. P., Rowley, C. N. & Yu, H. (2020). Polarisable force fields: what do they add in biomolecular simulations?. Current Opinion in Structural Biology, 61 182-190.

Scopus Eid


  • 2-s2.0-85078971610

Ro Full-text Url


  • https://ro.uow.edu.au/cgi/viewcontent.cgi?article=2191&context=smhpapers1

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/1177

Has Global Citation Frequency


Number Of Pages


  • 8

Start Page


  • 182

End Page


  • 190

Volume


  • 61

Place Of Publication


  • United Kingdom