© 1996-2012 IEEE. Intelligent Mechatronic Systems (IMS), such as intelligent vehicles/robots/transportation systems, are generally complex due to the integrations of artificial intelligence and multidisciplinary features taken from mechanical engineering, electrical engineering, and control engineering. This integrated complexity leads to challenges in reliability modeling and reliability testing due to different and complex failure modes. To achieve reliability requirements, reliability design and resilient control are critical for the development of IMS. With the advances in information and network techniques, it is opportunistic to exploit them for the benefit of reliability design and the resilient control. The main focus of this Focused Section will be on the new techniques in reliability modeling, reliability analysis, reliability design, fault and failure detection, signal processing, and resilient control of IMS.