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Dasymaschalolactams A-E, Aristolactams from a Twig Extract of Dasymaschalon dasymaschalum

Journal Article


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Abstract


  • Five new aristolactam alkaloids (1-5), dasymaschalolactams A-E, and the first isolation of dasymaschalolactone (17) as a natural product, together with 19 known compounds (6-16 and 18-25) were isolated from the twig extract of Dasymaschalon dasymaschalum. Their structures were elucidated by spectroscopic methods as well as comparisons made from the literature. Compounds 20 and 21 showed α-glucosidase inhibitory activities with IC50 values of 4.5 and 24.7 μM, respectively.

UOW Authors


  •   Suthiphasilp, Virayu (external author)
  •   Maneerat, Wisanu (external author)
  •   Andersen, Raymond J. (external author)
  •   Phukhatmuen, Piyaporn (external author)
  •   Pyne, Stephen
  •   Laphookhieo, Surat (external author)

Publication Date


  • 2019

Citation


  • Suthiphasilp, V., Maneerat, W., Andersen, R. J., Phukhatmuen, P., Pyne, S. G. & Laphookhieo, S. (2019). Dasymaschalolactams A-E, Aristolactams from a Twig Extract of Dasymaschalon dasymaschalum. Journal of Natural Products, 82 (11), 3176-3180.

Scopus Eid


  • 2-s2.0-85074594326

Ro Full-text Url


  • https://ro.uow.edu.au/cgi/viewcontent.cgi?article=2047&context=smhpapers1

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/1033

Number Of Pages


  • 4

Start Page


  • 3176

End Page


  • 3180

Volume


  • 82

Issue


  • 11

Place Of Publication


  • United States

Abstract


  • Five new aristolactam alkaloids (1-5), dasymaschalolactams A-E, and the first isolation of dasymaschalolactone (17) as a natural product, together with 19 known compounds (6-16 and 18-25) were isolated from the twig extract of Dasymaschalon dasymaschalum. Their structures were elucidated by spectroscopic methods as well as comparisons made from the literature. Compounds 20 and 21 showed α-glucosidase inhibitory activities with IC50 values of 4.5 and 24.7 μM, respectively.

UOW Authors


  •   Suthiphasilp, Virayu (external author)
  •   Maneerat, Wisanu (external author)
  •   Andersen, Raymond J. (external author)
  •   Phukhatmuen, Piyaporn (external author)
  •   Pyne, Stephen
  •   Laphookhieo, Surat (external author)

Publication Date


  • 2019

Citation


  • Suthiphasilp, V., Maneerat, W., Andersen, R. J., Phukhatmuen, P., Pyne, S. G. & Laphookhieo, S. (2019). Dasymaschalolactams A-E, Aristolactams from a Twig Extract of Dasymaschalon dasymaschalum. Journal of Natural Products, 82 (11), 3176-3180.

Scopus Eid


  • 2-s2.0-85074594326

Ro Full-text Url


  • https://ro.uow.edu.au/cgi/viewcontent.cgi?article=2047&context=smhpapers1

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/1033

Number Of Pages


  • 4

Start Page


  • 3176

End Page


  • 3180

Volume


  • 82

Issue


  • 11

Place Of Publication


  • United States