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Technical advances in X-ray microbeam radiation therapy

Journal Article


Abstract


  • In the last 25 years microbeam radiation therapy (MRT) has emerged as a promising alternative

    to conventional radiation therapy at large, third generation synchrotrons. In MRT, a multi-slit

    collimator modulates a kilovoltage x-ray beam on a micrometer scale, creating peak dose areas with

    unconventionally high doses of several hundred Grays separated by low dose valley regions, where

    the dose remains well below the tissue tolerance level. Pre-clinical evidence demonstrates that such

    beam geometries lead to substantially reduced damage to normal tissue at equal tumour control rates

    and hence drastically increase the therapeutic window. Although the mechanisms behind MRT are

    still to be elucidated, previous studies indicate that immune response, tumour microenvironment,

    and the microvasculature may play a crucial role. Beyond tumour therapy, MRT has also been

    suggested as a microsurgical tool in neurological disorders and as a primer for drug delivery

UOW Authors


  •   Bartzsch, Stefan (external author)
  •   Corde, Stephanie B. (external author)
  •   Crosbie, Jeffrey C. (external author)
  •   Day, Liam Robert James (external author)
  •   Donzelli, Mattia (external author)
  •   Krisch, Michael (external author)
  •   Lerch, Michael
  •   Pellicioli, Paolo (external author)
  •   Smyth, Lloyd M L (external author)
  •   Tehei, Moeava

Publication Date


  • 2020

Citation


  • Bartzsch, S., Corde, S., Crosbie, J. C., Day, L., Donzelli, M., Krisch, M., Lerch, M., Pellicioli, P., Smyth, L. M L. & Tehei, M. (2020). Technical advances in X-ray microbeam radiation therapy. Physics in Medicine & Biology, 65 02TR01-1-02TR01-20.

Scopus Eid


  • 2-s2.0-85078509991

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers1/3535

Start Page


  • 02TR01-1

End Page


  • 02TR01-20

Volume


  • 65

Place Of Publication


  • United Kingdom

Abstract


  • In the last 25 years microbeam radiation therapy (MRT) has emerged as a promising alternative

    to conventional radiation therapy at large, third generation synchrotrons. In MRT, a multi-slit

    collimator modulates a kilovoltage x-ray beam on a micrometer scale, creating peak dose areas with

    unconventionally high doses of several hundred Grays separated by low dose valley regions, where

    the dose remains well below the tissue tolerance level. Pre-clinical evidence demonstrates that such

    beam geometries lead to substantially reduced damage to normal tissue at equal tumour control rates

    and hence drastically increase the therapeutic window. Although the mechanisms behind MRT are

    still to be elucidated, previous studies indicate that immune response, tumour microenvironment,

    and the microvasculature may play a crucial role. Beyond tumour therapy, MRT has also been

    suggested as a microsurgical tool in neurological disorders and as a primer for drug delivery

UOW Authors


  •   Bartzsch, Stefan (external author)
  •   Corde, Stephanie B. (external author)
  •   Crosbie, Jeffrey C. (external author)
  •   Day, Liam Robert James (external author)
  •   Donzelli, Mattia (external author)
  •   Krisch, Michael (external author)
  •   Lerch, Michael
  •   Pellicioli, Paolo (external author)
  •   Smyth, Lloyd M L (external author)
  •   Tehei, Moeava

Publication Date


  • 2020

Citation


  • Bartzsch, S., Corde, S., Crosbie, J. C., Day, L., Donzelli, M., Krisch, M., Lerch, M., Pellicioli, P., Smyth, L. M L. & Tehei, M. (2020). Technical advances in X-ray microbeam radiation therapy. Physics in Medicine & Biology, 65 02TR01-1-02TR01-20.

Scopus Eid


  • 2-s2.0-85078509991

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers1/3535

Start Page


  • 02TR01-1

End Page


  • 02TR01-20

Volume


  • 65

Place Of Publication


  • United Kingdom