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DSB proteins and bacterial pathogenicity

Journal Article


Abstract


  • If DNA is the information of life, then proteins are the machines of life - but they must be assembled and correctly folded to function. A key step in the protein-folding pathway is the introduction of disulphide bonds between cysteine residues in a process called oxidative protein folding. Many bacteria use an oxidative protein-folding machinery to assemble proteins that are essential for cell integrity and to produce virulence factors. Although our current knowledge of this machinery stems largely from Escherichia coli K-12, this view must now be adjusted to encompass the wider range of disulphide catalytic systems present in bacteria.

UOW Authors


  •   Heras, Begona (external author)
  •   Shouldice, Stephen (external author)
  •   Totsika, Makrina (external author)
  •   Scanlon, Martin J. (external author)
  •   Schembri, Mark A. (external author)
  •   Martin, Jennifer

Publication Date


  • 2009

Citation


  • Heras, B., Shouldice, S. R., Totsika, M., Scanlon, M. J., Schembri, M. A. & Martin, J. L. (2009). DSB proteins and bacterial pathogenicity. Nature Reviews Microbiology, 7 (3), 215-225.

Scopus Eid


  • 2-s2.0-60749109471

Number Of Pages


  • 10

Start Page


  • 215

End Page


  • 225

Volume


  • 7

Issue


  • 3

Place Of Publication


  • United Kingdom

Abstract


  • If DNA is the information of life, then proteins are the machines of life - but they must be assembled and correctly folded to function. A key step in the protein-folding pathway is the introduction of disulphide bonds between cysteine residues in a process called oxidative protein folding. Many bacteria use an oxidative protein-folding machinery to assemble proteins that are essential for cell integrity and to produce virulence factors. Although our current knowledge of this machinery stems largely from Escherichia coli K-12, this view must now be adjusted to encompass the wider range of disulphide catalytic systems present in bacteria.

UOW Authors


  •   Heras, Begona (external author)
  •   Shouldice, Stephen (external author)
  •   Totsika, Makrina (external author)
  •   Scanlon, Martin J. (external author)
  •   Schembri, Mark A. (external author)
  •   Martin, Jennifer

Publication Date


  • 2009

Citation


  • Heras, B., Shouldice, S. R., Totsika, M., Scanlon, M. J., Schembri, M. A. & Martin, J. L. (2009). DSB proteins and bacterial pathogenicity. Nature Reviews Microbiology, 7 (3), 215-225.

Scopus Eid


  • 2-s2.0-60749109471

Number Of Pages


  • 10

Start Page


  • 215

End Page


  • 225

Volume


  • 7

Issue


  • 3

Place Of Publication


  • United Kingdom