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Production and Antifungal Activity of Cordytropolone and (-)-Leptosphaerone A From the Fungus Polycephalomyces nipponicus

Journal Article


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Abstract


  • Cordytropolone (1) and (−)-leptosphaerone A (2) were isolated from the culture broth of the fungus Polycephalomyces nip-ponicus. The structures of these two compounds were elucidated by spectroscopic methods and from a comparison of the spectroscopic data with those reported previously. The structure of 1 was confirmed by X-ray crystallography for the first time while the leptosphaerone class (compound 2) was first isolated as its (+)-antipode from the fungus Polycephalomyces(Cordyceps). The fermentation process was monitored weekly by High performance liquid chromatography analysis for 10 weeks. The predominant compound (1) was produced at ~0.65 mg/mg of dry extract at week 9. Compound 1 exhibited modest antipathogenic fungal activity against Collectrichum musae, Colletotrichum capsici, Colletotrichum gloeosporioides, Fusariumspp. TFPK301, F. spp. FOC1708, and Pestalotia spp. with percentage of mycelial growth inhibition values of 3.74 ± 0.70%, 12.86 ± 1.43%, 0.91 ± 0.56%, 5.46 ± 0.56%, 7.93 ± 0.61%, and 18.75 ± 5.24%, respectively, at 25 μg/mL.

UOW Authors


  •   Surapong, Kae (external author)
  •   Sangdee, Aphidech (external author)
  •   Chainok, Kittipong (external author)
  •   Pyne, Stephen
  •   Seephonkai, Prapairat (external author)

Publication Date


  • 2019

Citation


  • Surapong, N., Sangdee, A., Chainok, K., Pyne, S. G. & Seephonkai, P. (2019). Production and Antifungal Activity of Cordytropolone and (-)-Leptosphaerone A From the Fungus Polycephalomyces nipponicus. Natural Product Communications: an international journal for communications and reviews, 14 (5), 1-5.

Scopus Eid


  • 2-s2.0-85066397870

Ro Full-text Url


  • https://ro.uow.edu.au/cgi/viewcontent.cgi?article=1730&context=smhpapers1

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/716

Number Of Pages


  • 4

Start Page


  • 1

End Page


  • 5

Volume


  • 14

Issue


  • 5

Place Of Publication


  • United States

Abstract


  • Cordytropolone (1) and (−)-leptosphaerone A (2) were isolated from the culture broth of the fungus Polycephalomyces nip-ponicus. The structures of these two compounds were elucidated by spectroscopic methods and from a comparison of the spectroscopic data with those reported previously. The structure of 1 was confirmed by X-ray crystallography for the first time while the leptosphaerone class (compound 2) was first isolated as its (+)-antipode from the fungus Polycephalomyces(Cordyceps). The fermentation process was monitored weekly by High performance liquid chromatography analysis for 10 weeks. The predominant compound (1) was produced at ~0.65 mg/mg of dry extract at week 9. Compound 1 exhibited modest antipathogenic fungal activity against Collectrichum musae, Colletotrichum capsici, Colletotrichum gloeosporioides, Fusariumspp. TFPK301, F. spp. FOC1708, and Pestalotia spp. with percentage of mycelial growth inhibition values of 3.74 ± 0.70%, 12.86 ± 1.43%, 0.91 ± 0.56%, 5.46 ± 0.56%, 7.93 ± 0.61%, and 18.75 ± 5.24%, respectively, at 25 μg/mL.

UOW Authors


  •   Surapong, Kae (external author)
  •   Sangdee, Aphidech (external author)
  •   Chainok, Kittipong (external author)
  •   Pyne, Stephen
  •   Seephonkai, Prapairat (external author)

Publication Date


  • 2019

Citation


  • Surapong, N., Sangdee, A., Chainok, K., Pyne, S. G. & Seephonkai, P. (2019). Production and Antifungal Activity of Cordytropolone and (-)-Leptosphaerone A From the Fungus Polycephalomyces nipponicus. Natural Product Communications: an international journal for communications and reviews, 14 (5), 1-5.

Scopus Eid


  • 2-s2.0-85066397870

Ro Full-text Url


  • https://ro.uow.edu.au/cgi/viewcontent.cgi?article=1730&context=smhpapers1

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/716

Number Of Pages


  • 4

Start Page


  • 1

End Page


  • 5

Volume


  • 14

Issue


  • 5

Place Of Publication


  • United States