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Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA

Journal Article


Abstract


  • The advancement of multidisciplinary research fields dealing with ionising radiation induced biological damage – radiobiology, radiation physics, radiation protection and, in particular, medical physics – requires a clear mechanistic understanding of how cellular damage is induced by ionising radiation. Monte Carlo (MC) simulations provide a promising approach for the mechanistic simulation of radiation transport and radiation chemistry, towards the in silico simulation of early biological damage. We have recently developed a fully integrated MC simulation that calculates early single strand breaks (SSBs) and double strand breaks (DSBs) in a fractal chromatin based human cell nucleus model. The results of this simulation are almost equivalent to past MC simulations when considering direct/indirect strand break fraction, DSB yields and fragment distribution. The simulation results agree with experimental data on DSB yields within 13.6% on average and fragment distributions agree within an average of 34.8%.

Authors


  •   Sakata, Dosatsu (external author)
  •   Lampe, Nathanael (external author)
  •   Karamitros, Mathieu (external author)
  •   Kyriakou, Ioanna (external author)
  •   Belov, Oleg (external author)
  •   Bernal, Mario (external author)
  •   Bolst, David
  •   Bordage, Marie-Claude (external author)
  •   Breton, Vincent (external author)
  •   Brown, Jeremy M.
  •   Francis, Ziad (external author)
  •   Ivanchenko, V N. (external author)
  •   Meylan, S (external author)
  •   Murakami, Koichi (external author)
  •   Okada, Shogo (external author)
  •   Petrovic, Ivan (external author)
  •   Ristic-Fira, Aleksandra (external author)
  •   Santin, Giovanni (external author)
  •   Sarramia, David (external author)
  •   Sasaki, Takashi (external author)
  •   Shin, Wook (external author)
  •   Tang, Nicolas (external author)
  •   Tran, H N. (external author)
  •   Villagrasa, C (external author)
  •   Emfietzoglou, Dimitris (external author)
  •   Nieminen, Petteri (external author)
  •   Guatelli, Susanna
  •   Incerti, Sebastien (external author)

Publication Date


  • 2019

Citation


  • Sakata, D., Lampe, N., Karamitros, M., Kyriakou, I., Belov, O., Bernal, M. A., Bolst, D., Bordage, M., Breton, V., Brown, J. M. C., Francis, Z., Ivanchenko, V., Meylan, S., Murakami, K., Okada, S., Petrovic, I., Ristic-Fira, A., Santin, G., Sarramia, D., Sasaki, T., Shin, W., Tang, N., Tran, H. N., Villagrasa, C., Emfietzoglou, D., Nieminen, P., Guatelli, S. & Incerti, S. (2019). Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA. Physica Medica: an international journal devoted to the applications of physics to medicine and biology, 62 152-157.

Scopus Eid


  • 2-s2.0-85065792241

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers1/2863

Number Of Pages


  • 5

Start Page


  • 152

End Page


  • 157

Volume


  • 62

Place Of Publication


  • United Kingdom

Abstract


  • The advancement of multidisciplinary research fields dealing with ionising radiation induced biological damage – radiobiology, radiation physics, radiation protection and, in particular, medical physics – requires a clear mechanistic understanding of how cellular damage is induced by ionising radiation. Monte Carlo (MC) simulations provide a promising approach for the mechanistic simulation of radiation transport and radiation chemistry, towards the in silico simulation of early biological damage. We have recently developed a fully integrated MC simulation that calculates early single strand breaks (SSBs) and double strand breaks (DSBs) in a fractal chromatin based human cell nucleus model. The results of this simulation are almost equivalent to past MC simulations when considering direct/indirect strand break fraction, DSB yields and fragment distribution. The simulation results agree with experimental data on DSB yields within 13.6% on average and fragment distributions agree within an average of 34.8%.

Authors


  •   Sakata, Dosatsu (external author)
  •   Lampe, Nathanael (external author)
  •   Karamitros, Mathieu (external author)
  •   Kyriakou, Ioanna (external author)
  •   Belov, Oleg (external author)
  •   Bernal, Mario (external author)
  •   Bolst, David
  •   Bordage, Marie-Claude (external author)
  •   Breton, Vincent (external author)
  •   Brown, Jeremy M.
  •   Francis, Ziad (external author)
  •   Ivanchenko, V N. (external author)
  •   Meylan, S (external author)
  •   Murakami, Koichi (external author)
  •   Okada, Shogo (external author)
  •   Petrovic, Ivan (external author)
  •   Ristic-Fira, Aleksandra (external author)
  •   Santin, Giovanni (external author)
  •   Sarramia, David (external author)
  •   Sasaki, Takashi (external author)
  •   Shin, Wook (external author)
  •   Tang, Nicolas (external author)
  •   Tran, H N. (external author)
  •   Villagrasa, C (external author)
  •   Emfietzoglou, Dimitris (external author)
  •   Nieminen, Petteri (external author)
  •   Guatelli, Susanna
  •   Incerti, Sebastien (external author)

Publication Date


  • 2019

Citation


  • Sakata, D., Lampe, N., Karamitros, M., Kyriakou, I., Belov, O., Bernal, M. A., Bolst, D., Bordage, M., Breton, V., Brown, J. M. C., Francis, Z., Ivanchenko, V., Meylan, S., Murakami, K., Okada, S., Petrovic, I., Ristic-Fira, A., Santin, G., Sarramia, D., Sasaki, T., Shin, W., Tang, N., Tran, H. N., Villagrasa, C., Emfietzoglou, D., Nieminen, P., Guatelli, S. & Incerti, S. (2019). Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA. Physica Medica: an international journal devoted to the applications of physics to medicine and biology, 62 152-157.

Scopus Eid


  • 2-s2.0-85065792241

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers1/2863

Number Of Pages


  • 5

Start Page


  • 152

End Page


  • 157

Volume


  • 62

Place Of Publication


  • United Kingdom