This paper describes the experimental investigation and Computational Fluid Dynamics (CFD) simulations of the dispersion of CO2 following high-pressure dense phase CO2 pipeline failure. A full-scale burst test was carried out to simulate a CO2 pipeline failure in the real world. The atmospheric dispersion of the CO2 following the explosive release was measured. The CFD models were validated against the experimental data. The models were then used to estimate the consequence distances related to CO2 dispersion following failure of pipelines with various diameters under different wind speeds. This approach provides a predictive formula for the consequence distances of CO2 transmission pipelines.