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Lubricin on Platinum Electrodes: A Low-Impedance Protein-Resistant Surface Towards Biomedical Implantation

Journal Article


Abstract


  • Biofouling on surfaces compromises the function of biomedical

    devices whose function involves contact with biological fluids.

    In the context of electrochemical devices, proteins are attracted

    to the surface via coaction of various forces (hydrogen bond,

    hydrophobic effect, and other polar interactions) and protein

    interaction with the surface can significantly alter the surface

    chemistry. In response to this issue, we have developed an

    efficient anti-biofouling surface that employs a glycoprotein,

    lubricin (LUB), and which generates low impedance layers

    compatible with electrochemical applications. Herein, we investigate

    how different LUB densities on platinum (Pt) electrodes

    affect the surface electrochemistry and its ability to prevent

    nonspecific adsorption of protein to the surface. Surfaces with

    higher densities of LUB were more resistant to protein

    adsorption. The LUB modified Pt electrodes were challenged in

    artificial perilymph (AP) media under passive and electrically

    stimulated conditions over 7-day periods throughout which the

    LUB layer retained its anti-biofouling and surface coating

    stability.

Authors


  •   Silva, Saimon M. (external author)
  •   Quigley, Anita F. (external author)
  •   Kapsa, Robert M. I.
  •   Greene, Wren W. (external author)
  •   Moulton, Simon E. (external author)

Publication Date


  • 2019

Citation


  • Silva, S. M., Quigley, A. F., Kapsa, R. M. I., Greene, G. W. & Moulton, S. E. (2019). Lubricin on Platinum Electrodes: A Low-Impedance Protein-Resistant Surface Towards Biomedical Implantation. ChemElectroChem, 6 (6), 1939-1943.

Number Of Pages


  • 4

Start Page


  • 1939

End Page


  • 1943

Volume


  • 6

Issue


  • 6

Place Of Publication


  • Germany

Abstract


  • Biofouling on surfaces compromises the function of biomedical

    devices whose function involves contact with biological fluids.

    In the context of electrochemical devices, proteins are attracted

    to the surface via coaction of various forces (hydrogen bond,

    hydrophobic effect, and other polar interactions) and protein

    interaction with the surface can significantly alter the surface

    chemistry. In response to this issue, we have developed an

    efficient anti-biofouling surface that employs a glycoprotein,

    lubricin (LUB), and which generates low impedance layers

    compatible with electrochemical applications. Herein, we investigate

    how different LUB densities on platinum (Pt) electrodes

    affect the surface electrochemistry and its ability to prevent

    nonspecific adsorption of protein to the surface. Surfaces with

    higher densities of LUB were more resistant to protein

    adsorption. The LUB modified Pt electrodes were challenged in

    artificial perilymph (AP) media under passive and electrically

    stimulated conditions over 7-day periods throughout which the

    LUB layer retained its anti-biofouling and surface coating

    stability.

Authors


  •   Silva, Saimon M. (external author)
  •   Quigley, Anita F. (external author)
  •   Kapsa, Robert M. I.
  •   Greene, Wren W. (external author)
  •   Moulton, Simon E. (external author)

Publication Date


  • 2019

Citation


  • Silva, S. M., Quigley, A. F., Kapsa, R. M. I., Greene, G. W. & Moulton, S. E. (2019). Lubricin on Platinum Electrodes: A Low-Impedance Protein-Resistant Surface Towards Biomedical Implantation. ChemElectroChem, 6 (6), 1939-1943.

Number Of Pages


  • 4

Start Page


  • 1939

End Page


  • 1943

Volume


  • 6

Issue


  • 6

Place Of Publication


  • Germany